GHRL and AGRP

Number of citations of the paper that reports this interaction (PubMedID 11196643)
619

Data Source:
HPRD (in vivo)

		GHRL	AGRP
Description		ghrelin and obestatin prepropeptide	agouti related neuropeptide
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Axon Secretory Granule Lumen Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse	Extracellular Space Golgi Lumen Neuronal Cell Body
	Molecular Function	G Protein-coupled Receptor Binding Protein Binding Growth Hormone-releasing Hormone Activity Protein Tyrosine Kinase Activator Activity Ghrelin Receptor Binding	Signaling Receptor Binding Neuropeptide Hormone Activity Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding
	Biological Process	Gastric Acid Secretion Negative Regulation Of Endothelial Cell Proliferation Glucose Metabolic Process G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Dendrite Development Negative Regulation Of Angiogenesis Growth Hormone Secretion Positive Regulation Of Insulin Secretion Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Gastric Emptying Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Growth Rate Negative Regulation Of Locomotion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Apoptotic Process Cortisol Secretion Positive Regulation Of MAPK Cascade Response To Estrogen Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Cartilage Development Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Positive Regulation Of Small Intestinal Transit Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Development Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Eating Behavior Positive Regulation Of Adipose Tissue Development Positive Regulation Of Gastric Mucosal Blood Circulation Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Vascular Endothelial Cell Proliferation	Neuropeptide Signaling Pathway Circadian Rhythm Feeding Behavior Adult Feeding Behavior Hormone-mediated Signaling Pathway Response To Insulin Eating Behavior Long-day Photoperiodism Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Positive Regulation Of Feeding Behavior
Pathways			FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) ghrelin levels ( 33852427)	Blood protein levels ( 30072576 29875488 28240269) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: ACE2 AGRP CNTN4 GHRHR GHSR LEP MLNR NPY SIL1 UBQLN1 UBQLN2	4 interacting genes: GHRL MC3R MC4R MC5R
Entrez ID		51738	181
HPRD ID		05638	09079
Ensembl ID		ENSG00000157017	ENSG00000159723
Uniprot IDs		Q9UBU3	C6SUN5 O00253
PDB IDs		1P7X 6H3E	1HYK 1MR0 2IQV
Enriched GO Terms of Interacting Partners?
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