LSM8 and DCP1A

Number of citations of the paper that reports this interaction (PubMedID 15231747)
57

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LSM8	DCP1A
Description		LSM8 homolog, U6 small nuclear RNA associated	decapping mRNA 1A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex	P-body Nucleus Cytoplasm Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Kinesin Binding Identical Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Catalytic Activity Methylguanosine-cap Decapping Protein Localization To Cytoplasmic Stress Granule
Pathways		mRNA Splicing - Major Pathway	mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 33627673 29891935) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Smoking initiation ( 33082346) Smoking status (current vs never) ( 33082346) Triglyceride levels ( 30108155)	Body mass index ( 26426971) Electrocardiographic traits ( 25055868) Erosive tooth wear (severe vs non-severe) ( 29898447) Heart rate ( 23583979) PR interval ( 32439900) Refractive error ( 32231278) Spontaneous preterm birth (preterm delivery) ( 25599974)
Interacting Genes		49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1	16 interacting genes: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 MIR15B NSMAF PAXIP1 PNRC2 RAD52 RITA1 SMAD4 TTF2 UPF1 YWHAG
Entrez ID		51691	55802
HPRD ID		06288	06113
Ensembl ID		ENSG00000128534	ENSG00000272886
Uniprot IDs		A4D0W0 O95777	Q9NPI6
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG	2WX3 4B6H
Enriched GO Terms of Interacting Partners?
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