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DCP1A

Description decapping mRNA 1A
Image
GO Annotations Cellular Component
  • P-body
  • Nucleus
  • Cytoplasm
  • Cytosol
  • Membrane
  • Cytoplasmic Ribonucleoprotein Granule
Molecular Function
  • MRNA Binding
  • Protein Binding
  • Enzyme Activator Activity
  • Hydrolase Activity
  • Kinesin Binding
  • Identical Protein Binding
Biological Process
  • Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
  • Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
  • Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
  • Positive Regulation Of Catalytic Activity
  • Methylguanosine-cap Decapping
  • Protein Localization To Cytoplasmic Stress Granule
Pathways
  • mRNA decay by 5' to 3' exoribonuclease
  • Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
  • Body mass index ( 26426971)
  • Electrocardiographic traits ( 25055868)
  • Erosive tooth wear (severe vs non-severe) ( 29898447)
  • Heart rate ( 23583979)
  • PR interval ( 32439900)
  • Refractive error ( 32231278)
  • Spontaneous preterm birth (preterm delivery) ( 25599974)
Interacting Genes 16 interacting genes: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 MIR15B NSMAF PAXIP1 PNRC2 RAD52 RITA1 SMAD4 TTF2 UPF1 YWHAG
Entrez ID 55802
HPRD ID 06113
Ensembl ID ENSG00000272886
Uniprot IDs Q9NPI6
PDB IDs 2WX3 4B6H
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025