ATP6V1H and PPP1R12C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ATP6V1H	PPP1R12C
Description		ATPase H+ transporting V1 subunit H	protein phosphatase 1 regulatory subunit 12C
Image			No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Lysosomal Membrane Cytosol Plasma Membrane Extracellular Exosome	Cytoplasm Cytoskeleton
	Molecular Function	Protein Binding ATP Hydrolysis Activity Enzyme Regulator Activity Proton-transporting ATPase Activity, Rotational Mechanism	Enzyme Inhibitor Activity Protein Binding Phosphatase Regulator Activity Protein Kinase Binding
	Biological Process	Endocytosis Vacuolar Acidification Regulation Of Macroautophagy Regulation Of Catalytic Activity Proton Transmembrane Transport	Signal Transduction Negative Regulation Of Catalytic Activity
Pathways		ROS and RNS production in phagocytes Nef Mediated CD4 Down-regulation Nef Mediated CD8 Down-regulation Insulin receptor recycling Transferrin endocytosis and recycling Blockage of phagosome acidification Amino acids regulate mTORC1 Ion channel transport
Drugs		Tiludronic acid
Diseases
GWAS		Bipolar disorder with mood-incongruent psychosis ( 23092984) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		10 interacting genes: ATP6V1E1 CDKN2B ETHE1 FLACC1 PPP1R12C SNPH SOX9 SPATA2 TANK TRIM14	27 interacting genes: ATP6V1H ATXN7 BHLHA9 C1orf109 CACNA1A CCDC185 CDC42BPA EHHADH EXOC3 FMR1 FXR1 FXR2 IL16 IMP3 MPRIP MYL2 NOD2 NXF1 PAFAH1B2 PPP1CB RBM17 SMAD3 SMARCA2 SPECC1L THOC1 TSFM USHBP1
Entrez ID		51606	54776
HPRD ID		10591	11452
Ensembl ID		ENSG00000047249	ENSG00000125503
Uniprot IDs		A0A024R7U9 A0A024R7X3 B3KUZ7 Q9UI12	Q9BZL4
PDB IDs		6WM2 6WM3 6WM4
Enriched GO Terms of Interacting Partners?
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