MBIP and VPS28

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		MBIP	VPS28
Description		MAP3K12 binding inhibitory protein 1	VPS28 subunit of ESCRT-I
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol	ESCRT I Complex Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Late Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding	Protein Binding Ubiquitin Binding Protein-containing Complex Binding
	Biological Process	Positive Regulation Of Gene Expression Negative Regulation Of Catalytic Activity Histone H3 Acetylation Positive Regulation Of JNK Cascade	Macroautophagy Negative Regulation Of Protein Ubiquitination Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Endocytosis
Pathways		HATs acetylate histones	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS		Hypertension ( 31513605) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335)	Blood metabolite levels ( 26401656) Educational attainment ( 25201988)
Interacting Genes		47 interacting genes: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR1 FXR2 ING5 KAT14 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 SHANK3 SMARCB1 STX11 TGIF2LY TRIM55 TRIM63 TSC1 TXLNA TXLNB VPS28 VTA1 WDR5	46 interacting genes: ABI2 ASF1A BEX2 BLZF1 CACNA1I CARD9 CBX5 CCDC146 CDK18 CEP57L1 COX5B FABP3 GABARAP GEM GLCCI1 GOLGA2 INCA1 LMO3 MBIP NRDE2 NXF1 PDCD6IP PNMA5 PRKAA2 PRKAB2 RASSF5 SAXO1 SHC3 SKIL SMN1 SMN2 SUOX TCF12 TCF4 TRIM27 TRIM54 TSG101 TSNAX UBA52 UBC USHBP1 USP2 VPS37A VPS37B VPS37C VPS52
Entrez ID		51562	51160
HPRD ID		14368	11675
Ensembl ID		ENSG00000151332	ENSG00000160948
Uniprot IDs		B2RCV0 Q9NS73	A0A0S2Z5H5 Q548N1 Q9UK41
PDB IDs			6VME
Enriched GO Terms of Interacting Partners?
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