HPCAL4 and SPRED1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HPCAL4	SPRED1
Description		hippocalcin like 4	sprouty related EVH1 domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component		Nucleoplasm Cytosol Plasma Membrane Caveola Cytoplasmic Vesicle
	Molecular Function	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	Signal Transduction Central Nervous System Development	Negative Regulation Of Protein Kinase Activity Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Vasculogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Deacetylation Negative Regulation Of Lens Fiber Cell Differentiation
Pathways			Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases
GWAS		Bone mineral density (Ward's triangle area) ( 27397699)	Bipolar disorder ( 20351715) Birth weight ( 31043758) Cognitive performance (processing speed) ( 31598132) Crohn's disease ( 23128233) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285)
Interacting Genes		17 interacting genes: ANKRD33 AQP4 CDSN CEACAM6 CNTROB DTX2 F3 FAM131C LITAF MSRA SCMH1 SPRED1 TEX13B TRPM5 TSC22D3 TTC12 UBE3A	37 interacting genes: ANKS1A AQP1 BEX2 BLZF1 C2orf68 CCDC185 CDKN1A CREB5 DNAJB11 FAM118B FAM90A1 GLYCTK HEXIM2 HPCAL4 HSF2BP IL16 KIT MAB21L3 MEOX2 NAGK NCALD OSGEP PIH1D2 PPP1CA PPP1R7 PRPF18 RCC1 RIN1 SPG21 SUV39H1 TSC22D1 TTC19 VSNL1 ZNF408 ZNF417 ZNF587 ZNF655
Entrez ID		51440	161742
HPRD ID		17113	11601
Ensembl ID		ENSG00000116983	ENSG00000166068
Uniprot IDs		B4DGW9 Q9UM19	Q7Z699
PDB IDs			3SYX 6V65 6V6F
Enriched GO Terms of Interacting Partners?
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