PDE4C and KLRK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PDE4C	KLRK1
Description		phosphodiesterase 4C	killer cell lectin like receptor K1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytosol Cilium Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Metal Ion Binding	Protein Binding Carbohydrate Binding Signaling Receptor Activity
	Biological Process	CAMP Catabolic Process Signal Transduction	Adaptive Immune Response Signal Transduction Natural Killer Cell Activation Cell Differentiation T Cell Costimulation Negative Regulation Of GTPase Activity Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Chemotaxis
Pathways		DARPP-32 events G alpha (s) signalling events	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling
Drugs		Caffeine Dyphylline Iloprost Amrinone Roflumilast Piclamilast Crisaborole Ibudilast Exisulind Trapidil
Diseases
GWAS		Abdominal subcutaneous adipose tissue volume ( 34128465) Apolipoprotein B levels ( 32203549) Body shape index ( 34021172) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 28240269) Interleukin-1-receptor antagonist levels ( 22205395) Obesity-related traits ( 23251661) Psoriasis ( 28537254)
Interacting Genes		10 interacting genes: DDIT4L GDF15 GSC2 KLRK1 MEOX1 MEOX2 OSGIN1 PAX6 SRI ZNF280A	8 interacting genes: HCST MICB PDE4C RAE1 RAET1E RAET1G TYROBP ULBP3
Entrez ID		5143	22914
HPRD ID		02529	17240
Ensembl ID		ENSG00000105650	ENSG00000213809
Uniprot IDs		O43849 P78505 Q08493 Q32MM7 Q7KYS4	A0A024RAP8 P26718
PDB IDs		1LXU 2QYM	1HYR 1KCG 1MPU 4PDC 4S0U
Enriched GO Terms of Interacting Partners?
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