KLRK1 and PDE4C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KLRK1	PDE4C
Description		killer cell lectin like receptor K1	phosphodiesterase 4C
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane	Extracellular Space Nucleus Cytosol Cilium Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Carbohydrate Binding Signaling Receptor Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Metal Ion Binding
	Biological Process	Adaptive Immune Response Signal Transduction Natural Killer Cell Activation Cell Differentiation T Cell Costimulation Negative Regulation Of GTPase Activity Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Chemotaxis	CAMP Catabolic Process Signal Transduction
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling	DARPP-32 events G alpha (s) signalling events
Drugs			Caffeine Dyphylline Iloprost Amrinone Roflumilast Piclamilast Crisaborole Ibudilast Exisulind Trapidil
Diseases
GWAS		Blood protein levels ( 28240269) Interleukin-1-receptor antagonist levels ( 22205395) Obesity-related traits ( 23251661) Psoriasis ( 28537254)	Abdominal subcutaneous adipose tissue volume ( 34128465) Apolipoprotein B levels ( 32203549) Body shape index ( 34021172) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: HCST MICB PDE4C RAE1 RAET1E RAET1G TYROBP ULBP3	10 interacting genes: DDIT4L GDF15 GSC2 KLRK1 MEOX1 MEOX2 OSGIN1 PAX6 SRI ZNF280A
Entrez ID		22914	5143
HPRD ID		17240	02529
Ensembl ID		ENSG00000213809	ENSG00000105650
Uniprot IDs		A0A024RAP8 P26718	O43849 P78505 Q08493 Q32MM7 Q7KYS4
PDB IDs		1HYR 1KCG 1MPU 4PDC 4S0U	1LXU 2QYM
Enriched GO Terms of Interacting Partners?
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