CSAD and SH2B1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
26

Data Source:
BioGRID (two hybrid)

		CSAD	SH2B1
Description		cysteine sulfinic acid decarboxylase	SH2B adaptor protein 1
Image
GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytosol Plasma Membrane
	Molecular Function	Aspartate 1-decarboxylase Activity Sulfinoalanine Decarboxylase Activity Pyridoxal Phosphate Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding
	Biological Process	L-cysteine Catabolic Process To Hypotaurine L-cysteine Catabolic Process To Taurine Taurine Biosynthetic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Positive Regulation Of SMAD Protein Signal Transduction
Pathways		Degradation of cysteine and homocysteine	Factors involved in megakaryocyte development and platelet production
Drugs		Pyridoxal phosphate Cysteine
Diseases
GWAS		Fulminant type 1 diabetes ( 30552108) Obesity-related traits ( 23251661)	Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 29381148 19079260 19079261 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908 21102463) Dental caries (decayed, missing and filled teeth) ( 31533690) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Obesity ( 23563607) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Waist circumference ( 25673412) Weight ( 19079260)
Interacting Genes		11 interacting genes: ANXA1 ANXA7 CDKN1A GSK3B NR1H2 PIN1 RAP1B RCC1 SH2B1 SMN1 TK1	17 interacting genes: CSAD EGFR ERBB2 ERBB3 ERBB4 FGFR3 FRS3 GRB2 IGF1R INSR JAK2 KIAA0319 MET NTRK1 NTRK2 RHBG SH2B2
Entrez ID		51380	25970
HPRD ID		16763	12336
Ensembl ID		ENSG00000139631	ENSG00000178188
Uniprot IDs		A0A024RAX7 Q86V02 Q96JQ3 Q9Y600	A0A024QZ92 A0A024QZC2 A0A024QZD2 B3KNV5 B4DLN5 Q9NRF2
PDB IDs		2JIS	5W3R
Enriched GO Terms of Interacting Partners?
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