UBR5 and PAIP2

Number of citations of the paper that reports this interaction (PubMedID 16601676)
49

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		UBR5	PAIP2
Description		ubiquitin protein ligase E3 component n-recognin 5	poly(A) binding protein interacting protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm	Cytoplasm
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity	Translation Repressor Activity, MRNA Regulatory Element Binding MRNA Binding Protein Binding Translation Repressor Activity
	Biological Process	Protein Polyubiquitination DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus Progesterone Receptor Signaling Pathway Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Histone H2A K63-linked Ubiquitination Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair	Spermatogenesis Memory Negative Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Long-term Synaptic Potentiation
Pathways
Drugs
Diseases
GWAS		Chromosomal aberration frequency (total) ( 31586183) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Type 2 diabetes (age of onset) ( 28060188)	Body mass index ( 26426971) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Malaria ( 31844061)
Interacting Genes		32 interacting genes: BARD1 CIB1 CIP2A CSPP1 DYRK2 ERG GSK3B KPNA1 KPNA2 KPNB1 MAPK1 MOAP1 MYC NR1I2 OTUD5 PAIP1 PAIP2 PCK1 PGR SATB1 SMAD2 SOX2 TCEA1 TOPBP1 TXNIP UBC UBE2A UBE2B UBE2D2 UBE2D3 UBE2L3 ZNF207	7 interacting genes: APP ELAVL1 PABPC1 PABPC5 RPL11 TRIM54 UBR5
Entrez ID		51366	51247
HPRD ID		06436	05726
Ensembl ID		ENSG00000104517	ENSG00000120727
Uniprot IDs		O95071	Q49AE6 Q9BPZ3
PDB IDs		1I2T 2QHO 3PT3	1JGN 3KUS 3KUT
Enriched GO Terms of Interacting Partners?
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