MS4A4A and ATP6V0E1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MS4A4A	ATP6V0E1
Description		membrane spanning 4-domains A4A	ATPase H+ transporting V0 subunit e1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane Plasma Membrane Raft	Lysosomal Membrane Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain
	Molecular Function	Protein Binding	Protein Binding Hydrolase Activity ATPase-coupled Ion Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process		Vacuolar Acidification Regulation Of Macroautophagy Transmembrane Transport Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs			Tiludronic acid
Diseases
GWAS		Alzheimer's disease (late onset) ( 21460841) Alzheimer's disease in APOE e4- carriers ( 25778476) C-reactive protein levels ( 30388399) Cerebrospinal fluid sTREM-2 levels ( 31413141) Fibrinogen levels ( 28107422)	Body mass index ( 27455349) PR interval ( 32439900)
Interacting Genes		14 interacting genes: ATP6V0E1 CLDN19 CMTM7 LPAR3 MAL NRG1 PLP1 RPRM RUSF1 SEC22A SERTM1 TMEM14B TMUB2 UPK1B	19 interacting genes: - APOD ATP6V1E1 CDIPT COL8A2 CXCL16 EMP1 GPR25 KIR2DL3 MAL2 MS4A13 MS4A4A NAT8 OPRM1 PLN SYT15 TMEM218 TMEM254 YIPF6
Entrez ID		51338	8992
HPRD ID		08408	04894
Ensembl ID		ENSG00000110079	ENSG00000113732
Uniprot IDs		A0A384MDW1 Q4JF27 Q96JQ5	O15342
PDB IDs			6WLW 6WM2 6WM3 6WM4
Enriched GO Terms of Interacting Partners?
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