TIMMDC1 and KIR2DL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TIMMDC1	KIR2DL4
Description		translocase of inner mitochondrial membrane domain containing 1	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Membrane Early Endosome Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding MHC Class Ib Receptor Activity
	Biological Process		Positive Regulation Of Natural Killer Cell Cytokine Production Cellular Defense Response Signal Transduction Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cellular Senescence
Pathways		Complex I biogenesis	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602) Primary biliary cholangitis ( 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 33272962 28714469) Systemic sclerosis ( 31672989)	Objective response to lithium treatment ( 26503763)
Interacting Genes		70 interacting genes: AGR3 ANKRD46 APOC2 APOC4 APOL3 APP ARL6IP6 ATP6AP2 BCAP31 C14orf180 C3orf52 C4orf3 C5orf46 CCL4 CDS2 CMTM2 CREB3L1 CYP4F12 DCBLD2 DIABLO DRAM1 EPGN FAM20B FAM210B FATE1 FXYD3 GJB2 GPR151 GPR152 GPX8 HGS HSD17B13 IFNA2 KIR2DL4 LHFPL5 MARCHF5 MFSD14B MFSD5 NDUFB11 NINJ1 PEX5 PIGF PTPN1 PTPRN RNF24 SCAMP5 SCD SERF1A SERF1B SERP2 SLC35E4 SLC35F6 SMO ST6GAL2 STX12 STX6 TMEM144 TMEM14B TMEM176A TMEM199 TMEM203 TMEM239 TMEM31 TMEM54 TMEM65 TMEM86A TVP23B UNC93A YIF1A YIPF1	9 interacting genes: BPIFA1 FCER1G FHL5 HLA-G INCA1 RBPMS RNF216 TIMMDC1 TRIP6
Entrez ID		51300	3805
HPRD ID		12817	16082
Ensembl ID		ENSG00000113845	ENSG00000189013
Uniprot IDs		C9JU35 Q9NPL8	A0A0B4J1S6 A0A376A929 Q99706
PDB IDs			3WYR
Enriched GO Terms of Interacting Partners?
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