HSD17B12 and AMBRA1

		HSD17B12	AMBRA1
Description		hydroxysteroid 17-beta dehydrogenase 12	autophagy and beclin 1 regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Fatty Acid Elongase Complex Integral Component Of Membrane Extracellular Matrix	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Cytosol Axoneme Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Fibronectin Binding Protein Binding Collagen Binding Heparin Binding Oxidoreductase Activity Long-chain-3-hydroxyacyl-CoA Dehydrogenase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Long-chain-fatty-acyl-CoA Reductase Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity 3-oxo-arachidoyl-CoA Reductase Activity 3-oxo-behenoyl-CoA Reductase Activity 3-oxo-lignoceroyl-CoA Reductase Activity 3-oxo-cerotoyl-CoA Reductase Activity	Protein Binding Ubiquitin Protein Ligase Binding GTPase Binding
	Biological Process	Fatty Acid Biosynthetic Process Estrogen Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Long-chain Fatty-acyl-CoA Biosynthetic Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Nervous System Development Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Mitochondrial Depolarisation
Pathways		Androgen biosynthesis Synthesis of very long-chain fatty acyl-CoAs	Macroautophagy
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Birth length ( 25281659) Body mass index ( 26961502 25673413 29273807) Chronotype ( 30696823) Coronary artery disease ( 29212778 33020668) Essential hypertension (time to event) ( 32589924) FEV1 ( 30804560) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Morning person ( 30696823) Neuroblastoma ( 22941191) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Sleep start time ( 33075057) Sporadic neuroblastoma ( 28545128) Type 2 diabetes ( 28566273 30297969) Waist circumference ( 28552196)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Immunoglobulin A ( 20694011) Insulin-related traits (multivariate analysis) ( 32002517) Normal facial asymmetry (angle of deformation score) ( 30631343) Schizophrenia ( 28991256 29483656 30285260) Selective IgA deficiency ( 27723758)
Interacting Genes		3 interacting genes: AMBRA1 UBQLN1 UBQLN2	20 interacting genes: ALX4 BECN1 CHUK CREM CUL4B GABARAP GABARAPL1 GABARAPL2 HSD17B12 KBTBD4 MAP1LC3A MAP1LC3B MAP1LC3C MTCH2 MTOR PEX11A RNF2 SLC35C1 SNCA UBE2D3
Entrez ID		51144	55626
HPRD ID		09989	10975
Ensembl ID		ENSG00000149084	ENSG00000110497
Uniprot IDs		Q53GQ0	A0A075B6T1 Q9C0C7
PDB IDs
Enriched GO Terms of Interacting Partners?
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