PRKN and GPR37

Number of citations of the paper that reports this interaction (PubMedID 11439185)
236

Data Source:
BioGRID (genetic interference)
HPRD (in vitro, in vivo)

		PRKN	GPR37
Description		parkin RBR E3 ubiquitin protein ligase	G protein-coupled receptor 37
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Postsynaptic Density Aggresome Nuclear Speck SCF Ubiquitin Ligase Complex Neuron Projection Perinuclear Region Of Cytoplasm Lewy Body Presynapse Mitochondrion-derived Vesicle Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	G Protein-coupled Receptor Binding Transcription Corepressor Activity Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Tubulin Binding SH3 Domain Binding Enzyme Binding Kinase Binding Protein Kinase Binding PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ubiquitin Binding Phospholipase Binding Protein-containing Complex Binding Chaperone Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding Ubiquitin-specific Protease Binding F-box Domain Binding	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Mitochondrial Fission Autophagy Of Mitochondrion Mitophagy Negative Regulation Of Protein Phosphorylation Startle Response Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Response To Oxidative Stress Mitochondrion Organization Central Nervous System Development Learning Adult Locomotory Behavior Proteasomal Protein Catabolic Process Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Mitochondrial Fusion Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Regulation Of Glucose Metabolic Process Free Ubiquitin Chain Polymerization Regulation Of Dopamine Secretion Macroautophagy Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Protein Binding Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lipid Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glucokinase Activity Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Synaptic Transmission, Glutamatergic Protein K29-linked Ubiquitination ERAD Pathway Regulation Of Dopamine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Cellular Protein Catabolic Process Protein K27-linked Ubiquitination Negative Regulation By Host Of Viral Genome Replication Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Insulin Secretion Protein Stabilization Positive Regulation Of Neurotransmitter Uptake Dopamine Uptake Involved In Synaptic Transmission Protein Autoubiquitination Regulation Of Mitochondrial Membrane Potential Zinc Ion Homeostasis Negative Regulation Of Cell Death Regulation Of Canonical Wnt Signaling Pathway Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Neuron Cellular Homeostasis Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Aggresome Assembly Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Manganese Ion Protein K6-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Fission Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Toxic Substance Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Mitochondrion To Lysosome Transport Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Neuron Death Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Primary Amine Oxidase Activity Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Synaptic Vesicle Transport Negative Regulation Of Oxidative Stress-induced Cell Death Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Dopamine Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Exosomal Secretion Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Dendrite Extension Negative Regulation Of Spontaneous Neurotransmitter Secretion Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Localization To Membrane Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Locomotion Involved In Locomotory Behavior Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways		PINK1-PRKN Mediated Mitophagy Josephin domain DUBs Aggrephagy Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS		Triglyceride levels in HIV infection ( 33109212)	Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 32341527 26237428) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)
Interacting Genes		130 interacting genes: ADRM1 AIMP2 ARRB1 ARRB2 ATXN3 BAG5 BCL2L1 CASK CASP1 CASP8 CCNB1 CCND1 CDC34 CDK5 CDKN1A CHPF COMMD1 CRX CUL1 DLG1 DLX2 DNM1L DYNLT1 DYRK1A EPS15 FAF1 FAM120A FBP1 FBXO7 FBXW7 GNL1 GPR37 GRIN2B GRSF1 GTPBP4 HDAC6 HEXD HSD17B10 IKBKG LSG1 MDM2 MEOX1 MEOX2 MFN1 MFN2 MRPL13 MRPL19 MRPL45 NDUFA4L2 NEK2 NKRF NQO1 PAFAH1B2 PDCD2 PICK1 PKM PLK1 PRKAA2 PSMA1 PSMA7 PSMC1 PSMC2 PSMC5 PSMD4 PTPN5 PTTG1 RAB7A RAC1 RAD1 RAD23A RALY RANBP2 RBCK1 REL RGS2 RGS3 RHOT2 SEPTIN4 SEPTIN5 SF3B2 SF3B3 SIM2 SNCA SNCAIP STUB1 SUMO1 SYT11 TCF4 TENT5C TOMM40 TOMM70 TP53 TRIP13 TUBA4A TUBB UBASH3A UBASH3B UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2O UBE2R2 UBE2S UBE2T UBE2V1 UBE2Z USP30 USP33 VDAC1 YWHAH ZNF622 ZNF746	51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11
Entrez ID		5071	2861
HPRD ID		03967	03992
Ensembl ID		ENSG00000185345	ENSG00000170775
Uniprot IDs		O60260 X5DR79	O15354
PDB IDs		1IYF 2JMO 4BM9 4I1F 4I1H 5C1Z 5C23 5C9V 5N2W 5N38 5TR5 6GLC 6HUE 6N13
Enriched GO Terms of Interacting Partners?
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