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PRKN and UBE2E3
Number of citations of the paper that reports this interaction (PubMedID
24647965
)
60
Data Source:
BioGRID
(pull down)
PRKN
UBE2E3
Description
parkin RBR E3 ubiquitin protein ligase
ubiquitin conjugating enzyme E2 E3
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Postsynaptic Density
Aggresome
Nuclear Speck
SCF Ubiquitin Ligase Complex
Neuron Projection
Perinuclear Region Of Cytoplasm
Lewy Body
Presynapse
Mitochondrion-derived Vesicle
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytosol
Molecular Function
G Protein-coupled Receptor Binding
Transcription Corepressor Activity
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Tubulin Binding
SH3 Domain Binding
Enzyme Binding
Kinase Binding
Protein Kinase Binding
PDZ Domain Binding
Hsp70 Protein Binding
Heat Shock Protein Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Histone Deacetylase Binding
Ubiquitin Binding
Phospholipase Binding
Protein-containing Complex Binding
Chaperone Binding
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Ubiquitin-specific Protease Binding
F-box Domain Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Mitochondrial Fission
Autophagy Of Mitochondrion
Mitophagy
Negative Regulation Of Protein Phosphorylation
Startle Response
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Response To Oxidative Stress
Mitochondrion Organization
Central Nervous System Development
Learning
Adult Locomotory Behavior
Proteasomal Protein Catabolic Process
Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Mitochondrial Fusion
Negative Regulation Of Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Regulation Of Glucose Metabolic Process
Free Ubiquitin Chain Polymerization
Regulation Of Dopamine Secretion
Macroautophagy
Protein Ubiquitination
Protein Deubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Protein Destabilization
Positive Regulation Of Protein Binding
Negative Regulation Of Actin Filament Bundle Assembly
Regulation Of Lipid Transport
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Glucokinase Activity
Cellular Response To Unfolded Protein
Response To Endoplasmic Reticulum Stress
Synaptic Transmission, Glutamatergic
Protein K29-linked Ubiquitination
ERAD Pathway
Regulation Of Dopamine Metabolic Process
Norepinephrine Metabolic Process
Dopamine Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Binding
Negative Regulation Of Neuron Apoptotic Process
Cellular Protein Catabolic Process
Protein K27-linked Ubiquitination
Negative Regulation By Host Of Viral Genome Replication
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Insulin Secretion
Protein Stabilization
Positive Regulation Of Neurotransmitter Uptake
Dopamine Uptake Involved In Synaptic Transmission
Protein Autoubiquitination
Regulation Of Mitochondrial Membrane Potential
Zinc Ion Homeostasis
Negative Regulation Of Cell Death
Regulation Of Canonical Wnt Signaling Pathway
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Neuron Cellular Homeostasis
Protein K63-linked Ubiquitination
Protein Localization To Mitochondrion
Aggresome Assembly
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Response To Manganese Ion
Protein K6-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Cellular Response To Toxic Substance
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Mitochondrion To Lysosome Transport
Regulation Of Cellular Response To Oxidative Stress
Negative Regulation Of Neuron Death
Positive Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Negative Regulation Of Primary Amine Oxidase Activity
Positive Regulation Of Protein Linear Polyubiquitination
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Oxidative Stress-induced Cell Death
Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Dopamine
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Exosomal Secretion
Positive Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Dendrite Extension
Negative Regulation Of Spontaneous Neurotransmitter Secretion
Positive Regulation Of Retrograde Transport, Endosome To Golgi
Negative Regulation Of Intralumenal Vesicle Formation
Positive Regulation Of Protein Localization To Membrane
Amyloid Fibril Formation
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Protein Polyubiquitination
Regulation Of Growth
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Pathways
PINK1-PRKN Mediated Mitophagy
Josephin domain DUBs
Aggrephagy
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Triglyceride levels in HIV infection (
33109212
)
Ankylosing spondylitis (
23749187
)
Basophil count (
32888494
)
Body mass index (
25673413
)
Celiac disease (
22057235
20190752
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Heel bone mineral density (
30598549
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Lymphocyte counts (
29403010
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
)
Number of sexual partners (
30643258
)
Obesity (
21552555
)
QT interval (
29213071
)
Red blood cell count (
32888494
27863252
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Serum alkaline phosphatase levels (
33547301
)
Sweet taste preference (
32572145
)
White blood cell count (
27863252
)
Interacting Genes
130 interacting genes:
ADRM1
AIMP2
ARRB1
ARRB2
ATXN3
BAG5
BCL2L1
CASK
CASP1
CASP8
CCNB1
CCND1
CDC34
CDK5
CDKN1A
CHPF
COMMD1
CRX
CUL1
DLG1
DLX2
DNM1L
DYNLT1
DYRK1A
EPS15
FAF1
FAM120A
FBP1
FBXO7
FBXW7
GNL1
GPR37
GRIN2B
GRSF1
GTPBP4
HDAC6
HEXD
HSD17B10
IKBKG
LSG1
MDM2
MEOX1
MEOX2
MFN1
MFN2
MRPL13
MRPL19
MRPL45
NDUFA4L2
NEK2
NKRF
NQO1
PAFAH1B2
PDCD2
PICK1
PKM
PLK1
PRKAA2
PSMA1
PSMA7
PSMC1
PSMC2
PSMC5
PSMD4
PTPN5
PTTG1
RAB7A
RAC1
RAD1
RAD23A
RALY
RANBP2
RBCK1
REL
RGS2
RGS3
RHOT2
SEPTIN4
SEPTIN5
SF3B2
SF3B3
SIM2
SNCA
SNCAIP
STUB1
SUMO1
SYT11
TCF4
TENT5C
TOMM40
TOMM70
TP53
TRIP13
TUBA4A
TUBB
UBASH3A
UBASH3B
UBB
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2H
UBE2J1
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2O
UBE2R2
UBE2S
UBE2T
UBE2V1
UBE2Z
USP30
USP33
VDAC1
YWHAH
ZNF622
ZNF746
98 interacting genes:
ACVR1
ARID3A
ARIH2
ARRDC3
ASXL2
ATXN1
BARD1
BRCA1
CADPS2
CBL
CHFR
CHUK
CNOT4
CUL1
CUL3
CUL4A
DAZAP2
DTX3
DTX3L
DZIP3
HERC4
HMGB1
HTT
IPO11
IRAK1
ITCH
KLHL42
LAG3
MARCHF5
MDM2
MID1
MID2
MKRN3
MUL1
NEDD4L
NFKBIA
OTUB1
PGPEP1
PICK1
PJA1
PRKN
RANGAP1
RBX1
RC3H2
RCBTB1
RFWD3
RING1
RMND5B
RNF11
RNF111
RNF114
RNF115
RNF126
RNF13
RNF130
RNF14
RNF150
RNF165
RNF166
RNF167
RNF181
RNF185
RNF2
RNF25
RNF31
RNF4
RNF43
RNF5
RNF8
SAE1
SIAH1
SPOP
STUB1
TGFBR1
TRIM2
TRIM27
TRIM32
TRIM37
TRIM38
TRIM39
TRIM45
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TTC3
UBA1
UBC
UBOX5
UFM1
WBP2
WWP2
ZNF746
ZNF804A
ZNRF1
ZNRF2
ZNRF4
Entrez ID
5071
10477
HPRD ID
03967
05000
Ensembl ID
ENSG00000185345
ENSG00000170035
Uniprot IDs
O60260
X5DR79
Q969T4
R4GNG6
PDB IDs
1IYF
2JMO
4BM9
4I1F
4I1H
5C1Z
5C23
5C9V
5N2W
5N38
5TR5
6GLC
6HUE
6N13
Enriched GO Terms of Interacting Partners
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