DEF6 and BEGAIN

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
HPRD (two hybrid)

		DEF6	BEGAIN
Description		DEF6 guanine nucleotide exchange factor	brain enriched guanylate kinase associated
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Perinuclear Region Of Cytoplasm	Cytoplasm Membrane Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding
	Biological Process	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Regulation Of Postsynaptic Neurotransmitter Receptor Activity
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle	Neurexins and neuroligins
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Height ( 18391951 33713608) Hip circumference adjusted for BMI ( 34021172) Lymphocyte counts ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 33493351 28714469) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Chronotype ( 30696823) Menarche (age at onset) ( 21102462) Metabolite levels ( 23823483) Refractive error ( 32231278)
Interacting Genes		32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688	49 interacting genes: ABLIM1 APP AQP1 ATPAF2 BAHD1 BCL11B BMP7 CATSPER1 CDC23 DDX6 DEF6 DLG1 DLG4 DTNB ENKD1 EVL FAM107A FAM161A FAM90A1 GEM GFI1B GMCL1 GUCD1 HDAC4 HGS HID1 KIAA0408 KIFC3 LENG1 MAB21L3 PRPF18 PRR35 QSOX1 RASAL3 RBL1 RIBC2 SAXO1 TRAF4 TRIM27 USP2 ZFP64 ZNF250 ZNF319 ZNF417 ZNF572 ZNF587 ZNF648 ZNF774 ZNF835
Entrez ID		50619	57596
HPRD ID		10869	06459
Ensembl ID		ENSG00000023892	ENSG00000183092
Uniprot IDs		Q9H4E7	Q9BUH8
PDB IDs
Enriched GO Terms of Interacting Partners?
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