BEGAIN and DDX6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		BEGAIN	DDX6
Description		brain enriched guanylate kinase associated	DEAD-box helicase 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane Synapse	Heterochromatin P-body Outer Dense Fiber Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Adherens Junction Cytoplasmic Stress Granule Membrane RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Concave Side Of Sperm Head Sperm Annulus
	Molecular Function	Protein Binding	RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity Protein Domain Specific Binding Cadherin Binding
	Biological Process	Regulation Of Postsynaptic Neurotransmitter Receptor Activity	Negative Regulation Of Translation Viral RNA Genome Packaging Stem Cell Population Maintenance P-body Assembly Stress Granule Assembly Negative Regulation Of Neuron Differentiation Spermatid Differentiation Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Pathways		Neurexins and neuroligins	mRNA decay by 5' to 3' exoribonuclease
Drugs			D-tartaric acid
Diseases
GWAS		Chronotype ( 30696823) Menarche (age at onset) ( 21102462) Metabolite levels ( 23823483) Refractive error ( 32231278)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 31959851 30929738 34103634 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune traits (pleiotropy) ( 30572963) Blood protein levels ( 30072576) Celiac disease ( 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Diffuse cutaneous systemic sclerosis ( 24387989) Height ( 25429064) Hip minimal joint space width ( 27701424) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469 19838195) Systemic sclerosis ( 24387989 31672989) Vitiligo ( 22951725)
Interacting Genes		49 interacting genes: ABLIM1 APP AQP1 ATPAF2 BAHD1 BCL11B BMP7 CATSPER1 CDC23 DDX6 DEF6 DLG1 DLG4 DTNB ENKD1 EVL FAM107A FAM161A FAM90A1 GEM GFI1B GMCL1 GUCD1 HDAC4 HGS HID1 KIAA0408 KIFC3 LENG1 MAB21L3 PRPF18 PRR35 QSOX1 RASAL3 RBL1 RIBC2 SAXO1 TRAF4 TRIM27 USP2 ZFP64 ZNF250 ZNF319 ZNF417 ZNF572 ZNF587 ZNF648 ZNF774 ZNF835	77 interacting genes: BEGAIN BEND7 BHLHB9 BIRC7 CALCOCO2 CCDC136 CCDC14 CEP70 CEP76 CNKSR3 CNOT1 DDX17 DES DISC1 DNAAF11 EDC3 EFHC2 ENTR1 FCHO1 GIGYF1 GOLGA2 HOOK2 IK IKZF1 INKA1 JAKMIP1 JUP KLC4 KRT34 KRT40 KRTAP10-3 KRTAP10-8 LZTS1 MAGED1 MESD MTUS2 NAB2 NONO PAK5 PDLIM7 PICK1 PNMA5 POU6F2 PRDM16 PRPH RAPGEF3 RBM11 RBM14 REL RO60 RUNDC3A SCYL1 SHMT1 SIPA1L2 SLAIN1 SORBS3 SPATA6 SRPK2 STAT1 TCF12 TCF4 TLE5 TP53BP2 TRAF2 TRIM27 TRIM37 TRIM54 U2AF2 USH1G VPS52 ZBTB10 ZBTB14 ZBTB43 ZBTB8A ZC2HC1C ZNF24 ZRANB1
Entrez ID		57596	1656
HPRD ID		06459	02638
Ensembl ID		ENSG00000183092	ENSG00000110367
Uniprot IDs		Q9BUH8	B2R858 P26196
PDB IDs			1VEC 2WAX 2WAY 4CRW 4CT4 4CT5 5ANR 6F9S 6S8S
Enriched GO Terms of Interacting Partners?
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