P4HA1 and CD48

		P4HA1	CD48
Description		prolyl 4-hydroxylase subunit alpha 1	CD48 molecule
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Procollagen-proline 4-dioxygenase Complex Intracellular Membrane-bounded Organelle	Plasma Membrane External Side Of Plasma Membrane Membrane Anchored Component Of Membrane Intrinsic Component Of Plasma Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding L-ascorbic Acid Binding Identical Protein Binding	Antigen Binding Protein Binding Signaling Receptor Activity
	Biological Process	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Collagen Fibril Organization	Regulation Of Adaptive Immune Response Defense Response T Cell Activation
Pathways		Collagen biosynthesis and modifying enzymes	Cell surface interactions at the vascular wall
Drugs		Ascorbic acid Proline Hydralazine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301)	Blood protein levels ( 30072576 29875488) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		4 interacting genes: CD48 MLF2 OGT SUMO2	20 interacting genes: ACKR1 BRIX1 C1orf68 CD2 CD244 CD247 DIO1 E2F2 EEF1D EFNA1 EFNA3 FYN GNAI3 IL18R1 IL18RAP LCK LY9 MAST2 OAZ3 P4HA1
Entrez ID		5033	962
HPRD ID		08901	00177
Ensembl ID		ENSG00000122884	ENSG00000117091
Uniprot IDs		P13674 Q5VSQ6	A0A087X1S7 P09326
PDB IDs		1TJC 2V5F 2YQ8 4BT8 4BT9 4BTA 4BTB	2EDO
Enriched GO Terms of Interacting Partners?
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