P2RY6 and MCFD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		P2RY6	MCFD2
Description		pyrimidinergic receptor P2Y6	multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane	Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	G Protein-coupled ADP Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled UDP Receptor Activity G Protein-coupled UTP Receptor Activity	Calcium Ion Binding Protein Binding
	Biological Process	Phagocytosis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Smooth Muscle Cell Migration Transepithelial Chloride Transport Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Prostaglandin E Stimulus Cellular Response To Purine-containing Compound Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Cellular Response To Pyrimidine Ribonucleotide	Protein Transport Vesicle-mediated Transport
Pathways		G alpha (q) signalling events P2Y receptors	COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification
Drugs			Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Refractive error ( 32231278)	Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Mean reticulocyte volume ( 32888494) Response to statin therapy ( 20339536)
Interacting Genes		16 interacting genes: HOXA1 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP5-9 KRTAP9-2 MCFD2 NBPF19 NOTCH2NLA PLSCR1 UNG	11 interacting genes: APP CLCA4 CMTM5 F8 IL1RL1 LMAN1 P2RY6 PNLIPRP1 SCD SLC35A1 SYS1
Entrez ID		5031	90411
HPRD ID		03906	09693
Ensembl ID		ENSG00000171631	ENSG00000180398
Uniprot IDs		A0A024R5I9 Q15077	B4DF17 Q8NI22
PDB IDs		2B6R	2VRG 3A4U 3LCP 3WHT 3WHU 3WNX 4YGB 4YGC 4YGD 4YGE
Enriched GO Terms of Interacting Partners?
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