SLC22A18 and RRM1

		SLC22A18	RRM1
Description		solute carrier family 22 member 18	ribonucleotide reductase catalytic subunit M1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane	Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body
	Molecular Function	Protein Binding Symporter Activity Solute:proton Antiporter Activity Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding
	Biological Process	Excretion Organic Cation Transport Xenobiotic Transport Proton Transmembrane Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye
Pathways		Organic cation transport Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)	Interconversion of nucleotide di- and triphosphates
Drugs			Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Bilirubin levels ( 19414484) Calcium levels ( 20705733) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 29083408) Malaria ( 31844061) Total bilirubin levels ( 29403010)	Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)
Interacting Genes		6 interacting genes: HSD17B11 NKX3-1 RNF167 RRM1 TLCD4 TMX2	22 interacting genes: BMI1 CDC42 CUZD1 LRIF1 NUP98 PPP1CC PSMD13 RGS4 RNF2 RNH1 RRM2 RRM2B SH2D3A SIRPA SLC22A18 SLC22A18AS SPINK1 STIM1 SUMO2 YWHAG ZFPM2 ZNF655
Entrez ID		5002	6240
HPRD ID		04024	01588
Ensembl ID		ENSG00000110628	ENSG00000167325
Uniprot IDs		E9PRM7 Q96BI1	B4DXD1 B4E0I8 E9PL69 P23921
PDB IDs			2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L 6LKM
Enriched GO Terms of Interacting Partners?
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