RFWD3 and ORC2

Number of citations of the paper that reports this interaction (PubMedID 33044890)
1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RFWD3	ORC2
Description		ring finger and WD repeat domain 3	origin recognition complex subunit 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm PML Body Site Of Double-strand Break Site Of DNA Damage	Chromosome, Telomeric Region Heterochromatin Origin Recognition Complex Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane
	Molecular Function	P53 Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity MDM2/MDM4 Family Protein Binding	DNA Replication Origin Binding Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation Protein Ubiquitination Chromosome Breakage Replication Fork Processing Mitotic G1 DNA Damage Checkpoint Signaling Interstrand Cross-link Repair Regulation Of DNA Damage Checkpoint	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Initiation
Pathways			E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Adult body size ( 32376654) Experiencing mood swings ( 29500382) Leukocyte telomere length ( 32109421) Multiple myeloma ( 27363682) Testicular germ cell tumor ( 28604728 28604732 23666239)	Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)
Interacting Genes		15 interacting genes: APP ORC1 ORC2 PCNA RAD51 RPA1 RPA3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W	31 interacting genes: BCS1L CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4-16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RFWD3 RIPPLY3 RPA1 RPA2 SHANK2 XRCC5
Entrez ID		55159	4999
HPRD ID		07678	03112
Ensembl ID		ENSG00000168411	ENSG00000115942
Uniprot IDs		Q6PCD5	A0A024R411 Q13416
PDB IDs		6CVZ	5C8H 5UJ8 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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