SIX6 and PRKCH

		SIX6	PRKCH
Description		SIX homeobox 6	protein kinase C eta
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Cytoplasm Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Enzyme Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Eye Development Regulation Of Transcription By RNA Polymerase II Visual Perception Animal Organ Morphogenesis	Protein Phosphorylation Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Peptidyl-serine Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Bicellular Tight Junction Assembly
Pathways			Effects of PIP2 hydrolysis G alpha (z) signalling events
Drugs
Diseases
GWAS		Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673 22419738 29891935 25173105 29452408 22570617) Gut microbiota (bacterial taxa) ( 27723756) Height ( 20881960 25429064) Medication use (antiglaucoma preparations and miotics) ( 31015401) Menarche (age at onset) ( 25231870) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 25631615 31798171 28073927) Refractive error ( 23396134 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Urinary sodium excretion ( 31409800) Vertical cup-disc ratio ( 31798171 25241763 28073927)	Asthma ( 32296059) Height ( 28552196) Obesity (early onset extreme) ( 23563609) Reading and spelling ( 23738518) Rheumatoid arthritis ( 30423114 22446963 24390342) Word reading ( 23738518) Yeast infection ( 28928442)
Interacting Genes		5 interacting genes: GTF2A1L PRKCH TLE1 TLE5 TMEM33	17 interacting genes: BANP BMP4 C14orf39 CDK2 FYN GSK3A ITGB2 NUMB PARD6A PPP1R14A PRKD1 PTPN11 SIX6 SRC ZBTB8OS ZFP36L1 ZFYVE1
Entrez ID		4990	5583
HPRD ID		07557	05669
Ensembl ID		ENSG00000184302	ENSG00000027075
Uniprot IDs		O95475 Q6P051	P24723
PDB IDs			2FK9 3TXO
Enriched GO Terms of Interacting Partners?
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