OGG1 and HUS1

Number of citations of the paper that reports this interaction (PubMedID 19615952)
16

Data Source:
BioGRID (affinity chromatography technology, pull down)

		OGG1	HUS1
Description		8-oxoguanine DNA glycosylase	HUS1 checkpoint clamp component
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrial Matrix Cytosol Nuclear Matrix Nuclear Speck Protein-containing Complex	Nucleus Nucleoplasm Nucleolus Cytosol Checkpoint Clamp Complex Site Of Double-strand Break
	Molecular Function	Damaged DNA Binding Endonuclease Activity Protein Binding Microtubule Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity Oxidized Purine DNA Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	Protein Binding
	Biological Process	Acute Inflammatory Response Base-excision Repair Base-excision Repair, AP Site Formation Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Aging Response To Radiation Response To Xenobiotic Stimulus Response To Light Stimulus Response To Estradiol Nucleotide-excision Repair, DNA Incision Negative Regulation Of Apoptotic Process Depurination Depyrimidination Response To Ethanol Response To Folic Acid Cellular Response To Cadmium Ion Negative Regulation Of Double-strand Break Repair Via Single-strand Annealing	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Regulation Of Protein Phosphorylation DNA Repair Nucleotide-excision Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus Response To UV Embryo Development Ending In Birth Or Egg Hatching Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Meiotic DNA Integrity Checkpoint Signaling Cellular Response To Ionizing Radiation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective OGG1 Substrate Binding Defective OGG1 Substrate Processing	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS			Gut microbiota alpha diversity (Shannon index) ( 33208821) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507)
Interacting Genes		7 interacting genes: CHGB HUS1 NEDD4L PRKCA RAD1 RAD9A XRCC1	28 interacting genes: C4orf46 CD200 DCUN1D5 DNAJC7 FEN1 GRIP1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 NTAQ1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SDCBP SIRT6 TDG TOPBP1 YWHAQ
Entrez ID		4968	3364
HPRD ID		03582	04787
Ensembl ID		ENSG00000114026	ENSG00000136273
Uniprot IDs		E5KPM5 E5KPM6 E5KPM7 E5KPM8 E5KPM9 E5KPN0 E5KPN1 O15527	A4D2F2 O60921
PDB IDs		1EBM 1FN7 1HU0 1KO9 1LWV 1LWW 1LWY 1M3H 1M3Q 1N39 1N3A 1N3C 1YQK 1YQL 1YQM 1YQR 2I5W 2NOB 2NOE 2NOF 2NOH 2NOI 2NOL 2NOZ 2XHI 3IH7 3KTU 5AN4 6RLW 6W0M 6W0R 6W13	3A1J 3G65 3GGR 6J8Y
Enriched GO Terms of Interacting Partners?
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