OGG1

Description		8-oxoguanine DNA glycosylase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrial Matrix Cytosol Nuclear Matrix Nuclear Speck Protein-containing Complex
	Molecular Function	Damaged DNA Binding Endonuclease Activity Protein Binding Microtubule Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity Oxidized Purine DNA Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Acute Inflammatory Response Base-excision Repair Base-excision Repair, AP Site Formation Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Aging Response To Radiation Response To Xenobiotic Stimulus Response To Light Stimulus Response To Estradiol Nucleotide-excision Repair, DNA Incision Negative Regulation Of Apoptotic Process Depurination Depyrimidination Response To Ethanol Response To Folic Acid Cellular Response To Cadmium Ion Negative Regulation Of Double-strand Break Repair Via Single-strand Annealing
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective OGG1 Substrate Binding Defective OGG1 Substrate Processing
Drugs
Diseases
GWAS
Interacting Genes		7 interacting genes: CHGB HUS1 NEDD4L PRKCA RAD1 RAD9A XRCC1
Entrez ID		4968
HPRD ID		03582
Ensembl ID		ENSG00000114026
Uniprot IDs		E5KPM5 E5KPM6 E5KPM7 E5KPM8 E5KPM9 E5KPN0 E5KPN1 O15527
PDB IDs		1EBM 1FN7 1HU0 1KO9 1LWV 1LWW 1LWY 1M3H 1M3Q 1N39 1N3A 1N3C 1YQK 1YQL 1YQM 1YQR 2I5W 2NOB 2NOE 2NOF 2NOH 2NOI 2NOL 2NOZ 2XHI 3IH7 3KTU 5AN4 6RLW 6W0M 6W0R 6W13
Enriched GO Terms of Interacting Partners?
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