OAT and TNFSF15

		OAT	TNFSF15
Description		ornithine aminotransferase	TNF superfamily member 15
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Ornithine-oxo-acid Transaminase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding Ornithine(lysine) Transaminase Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Visual Perception Arginine Catabolic Process To Proline Via Ornithine Arginine Catabolic Process To Glutamate L-proline Biosynthetic Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity
Pathways		Glutamate and glutamine metabolism	TNFs bind their physiological receptors
Drugs		Pyridoxal phosphate Ornithine Gabaculine Canaline
Diseases
GWAS			Asthma ( 32296059) Behcet's disease ( 33393726) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 30500874 21102463 32581322 26891255 23266558) Inflammatory bowel disease ( 27569725 18758464 23128233) Leprosy ( 20018961 25642632) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28425483 23000144 28062665 30643196) Ulcerative colitis ( 20848476 21297633) Ulcerative colitis or Crohn's disease ( 21699788)
Interacting Genes		6 interacting genes: FGFR2 NUDT3 OGT SLC35F6 TNFSF15 UBQLN4	9 interacting genes: DELEC1 FKBP15 OAT PTBP3 SLC46A2 SRSF11 TMEM126A TNFRSF25 TNFRSF6B
Entrez ID		4942	9966
HPRD ID		02021	04956
Ensembl ID		ENSG00000065154	ENSG00000181634
Uniprot IDs		A0A140VJQ4 P04181	A0A0U5JA19 O95150
PDB IDs		1GBN 1OAT 2BYJ 2BYL 2CAN 2OAT 5VWO 6HX7 6OIA 6V8C 6V8D 7JX9	2O0O 2QE3 2RE9 2RJK 2RJL 3K51 3MI8
Enriched GO Terms of Interacting Partners?
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