NUP88 and NUP98

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		NUP88	NUP98
Description		nucleoporin 88	nucleoporin 98 and 96 precursor
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Cytosol	Kinetochore Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Nuclear Body Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Intracellular Membrane-bounded Organelle Nuclear Pore Nuclear Basket Ribonucleoprotein Complex
	Molecular Function	Transporter Activity Protein Binding Structural Constituent Of Nuclear Pore	Transcription Coactivator Activity MRNA Binding Transporter Activity Protein Binding Nuclear Localization Sequence Binding Serine-type Peptidase Activity Structural Constituent Of Nuclear Pore Promoter-specific Chromatin Binding
	Biological Process	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Mitotic Cell Cycle MRNA Export From Nucleus Protein Import Into Nucleus	Proteolysis Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Positive Regulation Of Transcription, DNA-templated Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Nuclear Pore Complex Assembly
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events
Drugs
Diseases
GWAS		Adult body size ( 32376654) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494)	Malaria ( 31844061) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736)
Interacting Genes		9 interacting genes: AGTR1 CD82 DVL2 EFNB3 EOLA1 NUP214 NUP62 NUP98 TFIP11	30 interacting genes: APC CBFA2T3 CHMP5 CREBBP CSNK2A1 CYFIP1 EP300 HBE1 HDAC1 IPO5 KCNQ1 KPNB1 MUC2 NFX1 NUP133 NUP214 NUP62 NUP88 NXF1 PSMD13 RAE1 RCC1 RNH1 RRM1 SEC13 SLC22A18AS TNPO1 TNPO2 TPR UTRN
Entrez ID		4927	4928
HPRD ID		03974	03012
Ensembl ID		ENSG00000108559	ENSG00000110713
Uniprot IDs		B4DP20 Q99567	P52948
PDB IDs			1KO6 2Q5X 2Q5Y 3MMY 4OWR 5A9Q 6BZM
Enriched GO Terms of Interacting Partners?
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