NT5E and AFF1

Number of citations of the paper that reports this interaction (PubMedID 19956800)
97

Data Source:
BioGRID (two hybrid)

		NT5E	AFF1
Description		5'-nucleotidase ecto	AF4/FMR2 family member 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane Extracellular Exosome	Transcription Elongation Factor Complex Super Elongation Complex
	Molecular Function	Nucleotide Binding Protein Binding 5'-nucleotidase Activity Metal Ion Binding	Protein Binding
	Biological Process	AMP Catabolic Process DNA Metabolic Process Leukocyte Cell-cell Adhesion Dephosphorylation ADP Catabolic Process Adenosine Biosynthetic Process Negative Regulation Of Inflammatory Response	Regulation Of Gene Expression
Pathways		Nicotinate metabolism Pyrimidine catabolism Purine catabolism Purinergic signaling in leishmaniasis infection
Drugs		Pentoxifylline
Diseases
GWAS		Blood metabolite levels ( 24816252) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lung function ( 31902109) Metabolic traits ( 21886157) Serum metabolite levels ( 33031748)	Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549 33730874) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Bulimia nervosa ( 23568457) Diastolic blood pressure ( 28234671) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 29403010 32888494 27863252) Hematological and biochemical traits ( 31902109) Hemoglobin ( 29403010 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) PR interval ( 32439900) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Systemic lupus erythematosus ( 22291604) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549 32154731 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 20864672 30275531 25961943 20686565) White blood cell count (basophil) ( 29403010 27863252)
Interacting Genes		7 interacting genes: ACTB AFF1 ATP6AP1 FN1 LAMA1 RNF24 ZNRF4	10 interacting genes: ARFIP1 H3-4 MLLT1 MLLT3 NT5E SASH1 SIAH1 SIAH2 SMAD9 TBCA
Entrez ID		4907	4299
HPRD ID		00552	08871
Ensembl ID		ENSG00000135318	ENSG00000172493
Uniprot IDs		P21589 Q6NZX3	B4DJU9 P51825 Q14C88
PDB IDs		4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I 6HXW 6S7F 6S7H 6TVE 6TVG 6TVX 6TW0 6TWA 6TWF 6XUE 6XUG 6XUQ 6YE1 6YE2 6Z9B 6Z9D 7JV8 7JV9	2LM0
Enriched GO Terms of Interacting Partners?
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