NRF1 and BRWD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NRF1	BRWD1
Description		nuclear respiratory factor 1	bromodomain and WD repeat domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity	Molecular_function
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Cell Shape
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis	Interleukin-7 signaling Interleukin-7 signaling Chromatin modifying enzymes
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Apolipoprotein B levels ( 32203549) Cognitive function ( 25644384) Daytime nap ( 33568662) Daytime sleep phenotypes ( 27126917) General cognitive ability ( 29844566) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Menarche (age at onset) ( 25231870) Platelet distribution width ( 32888494) Smoking initiation ( 33082346) Temperament (bipolar disorder) ( 22365631) Total cholesterol levels ( 30275531)
Interacting Genes		48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC22A18AS SP2 SP4 SPSB2 SRARP TESMIN TEX43 TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6	15 interacting genes: ADD2 APP APPL1 CALM1 CUL4B EIF4E FNDC3B HDAC7 NRF1 NUTF2 SMARCA4 SMARCD1 STAT3 TRIM55 TRIM63
Entrez ID		4899	54014
HPRD ID		02930	11683
Ensembl ID		ENSG00000106459	ENSG00000185658
Uniprot IDs		A0A024R770 A0A024R774 Q16656	Q9NSI6
PDB IDs			3Q2E
Enriched GO Terms of Interacting Partners?
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