NNMT and ATF6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		NNMT	ATF6
Description		nicotinamide N-methyltransferase	activating transcription factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Nicotinamide N-methyltransferase Activity N-methyltransferase Activity Pyridine N-methyltransferase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding CAMP Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Nicotinamide Metabolic Process Response To Xenobiotic Stimulus Response To Organonitrogen Compound Regulation Of Polyamine Biosynthetic Process Regulation Of Histone Methylation Animal Organ Regeneration Methylation NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Gluconeogenesis Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Deacetylation	Eye Development Regulation Of Transcription By RNA Polymerase II Protein Folding Signal Transduction Visual Perception Positive Regulation Of Autophagy Endoplasmic Reticulum Unfolded Protein Response ATF6-mediated Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Methylation Nicotinamide salvaging Metabolism of ingested SeMet, Sec, MeSec into H2Se	ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes
Drugs		Niacin	Pseudoephedrine
Diseases
GWAS		Asthma ( 29273806) Diisocyanate-induced asthma ( 25918132) Volumetric brain MRI ( 17903297)	Chronic bronchitis in chronic obstructive pulmonary disease ( 25241909) Parkinson's disease (age of onset) ( 19772629) Systemic sclerosis ( 30247649)
Interacting Genes		4 interacting genes: APP ATF6 BIRC5 BMF	16 interacting genes: APP ATF6B BPGM CREB1 CREB3L3 DAPK1 DDC GTF2I MAGI1 NFYA NFYC NNMT SRF TNFRSF1A XBP1 YY1
Entrez ID		4837	22926
HPRD ID		02478	16118
Ensembl ID		ENSG00000166741	ENSG00000118217
Uniprot IDs		P40261 Q6FH49	A8K383 P18850
PDB IDs		2IIP 3ROD 5YJF 6B1A 6CHH 6ORR 6PVE 6PVS
Enriched GO Terms of Interacting Partners?
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