ATF6 and NNMT

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ATF6	NNMT
Description		activating transcription factor 6	nicotinamide N-methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane	Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding CAMP Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Nicotinamide N-methyltransferase Activity N-methyltransferase Activity Pyridine N-methyltransferase Activity
	Biological Process	Eye Development Regulation Of Transcription By RNA Polymerase II Protein Folding Signal Transduction Visual Perception Positive Regulation Of Autophagy Endoplasmic Reticulum Unfolded Protein Response ATF6-mediated Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Nicotinamide Metabolic Process Response To Xenobiotic Stimulus Response To Organonitrogen Compound Regulation Of Polyamine Biosynthetic Process Regulation Of Histone Methylation Animal Organ Regeneration Methylation NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Gluconeogenesis Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Deacetylation
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes	Methylation Nicotinamide salvaging Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs		Pseudoephedrine	Niacin
Diseases
GWAS		Chronic bronchitis in chronic obstructive pulmonary disease ( 25241909) Parkinson's disease (age of onset) ( 19772629) Systemic sclerosis ( 30247649)	Asthma ( 29273806) Diisocyanate-induced asthma ( 25918132) Volumetric brain MRI ( 17903297)
Interacting Genes		16 interacting genes: APP ATF6B BPGM CREB1 CREB3L3 DAPK1 DDC GTF2I MAGI1 NFYA NFYC NNMT SRF TNFRSF1A XBP1 YY1	4 interacting genes: APP ATF6 BIRC5 BMF
Entrez ID		22926	4837
HPRD ID		16118	02478
Ensembl ID		ENSG00000118217	ENSG00000166741
Uniprot IDs		A8K383 P18850	P40261 Q6FH49
PDB IDs			2IIP 3ROD 5YJF 6B1A 6CHH 6ORR 6PVE 6PVS
Enriched GO Terms of Interacting Partners?
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