NEFL and TSC1

Number of citations of the paper that reports this interaction (PubMedID 12226091)
14

Data Source:
HPRD (in vivo)

		NEFL	TSC1
Description		neurofilament light chain	TSC complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Neurofilament Axon Growth Cone Neuromuscular Junction Schaffer Collateral - CA1 Synapse Cholinergic Synapse Postsynaptic Intermediate Filament Cytoskeleton Presynaptic Intermediate Filament Cytoskeleton Axon Cytoplasm	Nucleus Cytoplasm Lipid Droplet Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Growth Cone Protein-containing Complex TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm Chaperone Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Phospholipase Binding Protein-containing Complex Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton	Protein Binding Hsp70 Protein Binding GTPase Activating Protein Binding ATPase Inhibitor Activity Protein-containing Complex Binding Protein N-terminus Binding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Anterograde Axonal Transport Retrograde Axonal Transport Response To Toxic Substance Peripheral Nervous System Axon Regeneration Axonal Transport Of Mitochondrion Spinal Cord Development Hippocampus Development Cerebral Cortex Development Regulation Of Axon Diameter Neurofilament Bundle Assembly Locomotion Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Intermediate Filament Polymerization Or Depolymerization Intermediate Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Neuromuscular Process Controlling Balance Protein Polymerization Response To Corticosterone Neurofilament Cytoskeleton Organization Synapse Maturation Postsynaptic Intermediate Filament Cytoskeleton Organization Response To Sodium Arsenite Response To Acrylamide	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion Adaptive Immune Response RRNA Export From Nucleus Regulation Of Translation Potassium Ion Transport Cell-matrix Adhesion Negative Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Neuron Projection Development Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Negative Regulation Of Translation Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Negative Regulation Of ATPase Activity Response To Insulin Negative Regulation Of GTPase Activity Myelination Memory T Cell Differentiation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Glucose Import Synapse Organization Protein Stabilization Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Activation Of GTPase Activity Cellular Response To Oxygen-glucose Deprivation Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Death
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs
Drugs
Diseases
GWAS		Fear of minor pain ( 28701861) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)	Migraine without aura ( 23793025) Psoriasis ( 19169254)
Interacting Genes		52 interacting genes: BRD7 CCDC13 CCDC172 CCDC33 CCNC CDK5RAP2 CEP57L1 CHD3 DES ENKD1 FXR1 GFAP GOLGA2 GORASP1 GRIN1 HGS KDM1A KIFC3 KLC3 KRT13 KRT15 KRT18 MAP2 MTMR2 MTUS2 MYO15B MYO5A NDN NEFH NEFM NEK6 NME7 PDE4DIP PIAS4 PKN1 PPP1R16B PPP1R18 PRMT6 SHANK3 SKIL SMYD1 SPTAN1 TERF1 TEX11 TRIM55 TRIM63 TSC1 TXLNB USHBP1 USP2 VIM YWHAG	179 interacting genes: ABI1 ACTN1 ACTN2 AKT1 ANKIB1 ANKRD24 ANKRD35 APPL2 AQP1 ARAF ARID5A ATN1 ATXN1 AURKA AXIN1 BAG3 BCL11A BECN1 BEND5 BRD3 C1orf94 CALCOCO2 CAPZA2 CASC3 CCDC120 CCDC88B CCL28 CCNB1 CCND2 CCNE1 CDK1 CDK4 CDK6 CDKN2A CDKN2B CDR2 CHCHD2 CNIH1 CNTRL CNTROB COG6 CSTF2 CTNNB1 DACH2 DCTN2 DMRT3 DOK5 EIF3A ENKD1 EZR FAM110A FAM222B FBF1 FCN1 FGFR4 FOLR2 FOXH1 FRS3 GCC1 GEMIN8 GFAP GLIS2 GOLGA2 GPANK1 GPATCH1 HECW1 HGS HNRNPM HOMER3 HOOK2 HOXC8 HR HSH2D ICA1 IGFN1 IKBKB KANSL2 KAT2A KAZN KDM1A KIF1C KIF5A KLC1 KLC4 LATS2 LENG1 LMO2 LRSAM1 LUC7L LZTS2 MAP2K5 MAPK14 MBIP MBP MSANTD3 MSN MT-ND1 MYC MYLIP MYOZ3 NDUFA9 NECAB2 NEFL NF2 NINL NKD2 NRBF2 PAEP PATL1 PATZ1 PHLDB1 PICK1 PITX1 PLK1 PLK2 POGZ POU6F2 PPFIA2 PPP1R18 PPP1R32 PRMT6 PTPA RALYL RASSF1 RBPMS RDX RHEB RIN1 RIN3 RUNDC3A SAMD11 SAMD7 SCMH1 SEC31A SELENOW SERTAD1 SH2D2A SHANK1 SHC3 SLC16A6 SMG9 SORBS3 SOX4 SPAG5 SPAG8 SUOX TANK TBC1D7 TBX6 TCF7L2 TFAP2D TFIP11 TLE5 TNS2 TRAF2 TRIM3 TRIOBP TSC2 TSGA10IP TSHZ3 TUBB4B VENTX VEZF1 VGLL3 VIM VPS37C YPEL3 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZIC1 ZNF417 ZNF423 ZNF587 ZNF765 ZNF79
Entrez ID		4747	7248
HPRD ID		01206	05594
Ensembl ID		ENSG00000277586	ENSG00000165699
Uniprot IDs		P07196	A0A2R8Y5S3 Q32NF0 Q86WV8 Q92574 X5D9D2
PDB IDs			4Z6Y 5EJC 7DL2
Enriched GO Terms of Interacting Partners?
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