PPP1R12B and PPP1CB

Number of citations of the paper that reports this interaction (PubMedID 9570949)
17

Data Source:
HPRD (in vitro)

		PPP1R12B	PPP1CB
Description		protein phosphatase 1 regulatory subunit 12B	protein phosphatase 1 catalytic subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Z Disc A Band	Protein Phosphatase Type 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Glycogen Granule Extracellular Exosome PTW/PP1 Phosphatase Complex
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Enzyme Activator Activity Phosphatase Regulator Activity Protein Kinase Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Myosin Phosphatase Activity Protein Kinase Binding Metal Ion Binding Myosin-light-chain-phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Regulation Of Muscle Contraction Signal Transduction Negative Regulation Of Catalytic Activity	MAPK Cascade Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Cell Cycle Regulation Of Cell Adhesion Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Cell Division
Pathways		RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	Triglyceride catabolism Downregulation of TGF-beta receptor signaling Regulation of PLK1 Activity at G2/M Transition Circadian Clock RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs
Diseases
GWAS		Celiac disease ( 23936387) Chronic obstructive pulmonary disease ( 32824824) Coronary heart disease ( 24778558) Obesity-related traits ( 23251661) Sex ratio ( 26763874)	Body mass index ( 25673413) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Excessive sweating ( 29895819) Heel bone mineral density ( 30598549 28869591) Pre-treatment viral load in HIV-1 infection ( 31219150) Pure non-grapefruit juice consumption ( 31046077)
Interacting Genes		3 interacting genes: IL16 PPP1CB PRKG1	51 interacting genes: AATK ACTN2 AURKA BRCA1 C14orf180 CHCHD3 CLK1 CLOCK CSNK2B CSRNP1 CSRNP2 CYSRT1 DELEC1 FBXO7 H3-3A H3C1 HOXA2 KANK2 KIF23 LMTK2 MAPT MEOX2 NCOA1 NONO PHACTR3 PPP1R11 PPP1R12B PPP1R12C PPP1R16A PPP1R16B PPP1R27 PPP1R2B PPP1R2C PPP1R3A PPP1R3B PPP1R3C PPP1R7 PPP1R9A PPP1R9B PPP2R5C PRKAR2A PTK2 RB1 RORC SH2D4A SPATC1L TLX1 TP53BP2 UBAC1 WBP11 ZFYVE9
Entrez ID		4660	5500
HPRD ID		04794	11792
Ensembl ID		ENSG00000077157	ENSG00000213639
Uniprot IDs		E1CKY7 O60237	P62140 V9HW04
PDB IDs
Enriched GO Terms of Interacting Partners?
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