MYH10 and XRN1

		MYH10	XRN1
Description		myosin heavy chain 10	5'-3' exoribonuclease 1
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytosol Polysome Cell Cortex Myosin Complex Myosin II Complex Lamellipodium Midbody Cleavage Furrow Actomyosin Extracellular Exosome Myosin II Filament	P-body Nucleus Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Synapse
	Molecular Function	Microfilament Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding RNA Stem-loop Binding ADP Binding MRNA 5'-UTR Binding Actin Filament Binding	G-quadruplex RNA Binding RNA Binding 5'-3' Exoribonuclease Activity Protein Binding G-quadruplex DNA Binding Telomerase RNA Binding
	Biological Process	Mitotic Cytokinesis Cell Adhesion Regulation Of Cell Shape Actin Filament-based Movement Actomyosin Structure Organization Positive Regulation Of Protein Secretion Modification Of Postsynaptic Actin Cytoskeleton	Nuclear-transcribed MRNA Catabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Puromycin
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Type 2 diabetes ( 30130595)	Benign childhood epilepsy with centro-temporal spikes ( 32580138) Birth weight ( 31043758) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Waist-hip ratio ( 28552196)
Interacting Genes		20 interacting genes: APC BCAP31 DUX4 ECPAS EIF4A1 FXR1 FXR2 GPS2 ITGAE MYH9 MYO1C PBX1 PTEN S100A4 SERPINF2 UBL4A XRN1 YWHAE YWHAG ZNF512B	67 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1P CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MIR34C MIR429 MIR7-1 MTCH2 MTREX MYH10 NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36
Entrez ID		4628	54464
HPRD ID		01178	10470
Ensembl ID		ENSG00000133026	ENSG00000114127
Uniprot IDs		G1UI33 P35580	Q8IZH2
PDB IDs		4PD3
Enriched GO Terms of Interacting Partners?
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