HiPPIP
Home
About
SZ Genes
People
Help
Advanced Search
MYD88 and FADD
Number of citations of the paper that reports this interaction (PubMedID
11828002
)
19
Data Source:
HPRD
(in vitro, in vivo)
MYD88
FADD
Description
MYD88 innate immune signal transduction adaptor
Fas associated via death domain
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Postsynaptic Density
Protein-containing Complex
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Neuron Projection
Cell Body
Membrane Raft
Ripoptosome
Molecular Function
NAD+ Nucleosidase Activity
Toll Binding
Death Receptor Binding
Interleukin-1 Receptor Binding
Protein Binding
Toll-like Receptor Binding
Identical Protein Binding
Protein Self-association
TIR Domain Binding
Protease Binding
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Tumor Necrosis Factor Receptor Superfamily Binding
Receptor Serine/threonine Kinase Binding
Death Effector Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Caspase Binding
Biological Process
Response To Molecule Of Fungal Origin
Leukocyte Activation Involved In Inflammatory Response
Neutrophil Activation Involved In Immune Response
MyD88-dependent Toll-like Receptor Signaling Pathway
Phagocytosis
Apoptotic Process
Signal Transduction
Cell Surface Receptor Signaling Pathway
JNK Cascade
Toll Signaling Pathway
Induced Systemic Resistance
Positive Regulation Of Gene Expression
Immunoglobulin Mediated Immune Response
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Peptidoglycan
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-23 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 8 Signaling Pathway
Defense Response To Bacterium
Defense Response To Protozoan
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of JNK Cascade
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Lymphocyte Proliferation
Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Type I Interferon Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
3'-UTR-mediated MRNA Stabilization
Neutrophil-mediated Killing Of Bacterium
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Establishment Of Endothelial Intestinal Barrier
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Regulation Of Neutrophil Migration
Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Kidney Development
Positive Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Adaptive Immune Response
Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
T Cell Differentiation In Thymus
TRAIL-activated Apoptotic Signaling Pathway
Positive Regulation Of Activated T Cell Proliferation
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Morphine
Innate Immune Response
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Proteolysis
Positive Regulation Of Transcription By RNA Polymerase II
Behavioral Response To Cocaine
Lymph Node Development
Spleen Development
Thymus Development
Defense Response To Virus
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Necroptotic Process
Negative Regulation Of Activation-induced Cell Death Of T Cells
Cellular Response To Mechanical Stimulus
Death-inducing Signaling Complex Assembly
Motor Neuron Apoptotic Process
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Activation Of Cysteine-type Endopeptidase Activity
Necroptotic Signaling Pathway
Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
ER-Phagosome pathway
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
RIP-mediated NFkB activation via ZBP1
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
MyD88 deficiency (TLR2/4)
MyD88 deficiency (TLR5)
IRAK4 deficiency (TLR5)
IRAK4 deficiency (TLR2/4)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Caspase activation via Death Receptors in the presence of ligand
TRIF-mediated programmed cell death
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
Regulation of necroptotic cell death
Dimerization of procaspase-8
FasL/ CD95L signaling
TRAIL signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Defective RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS
Gut microbiota (bacterial taxa) (
27723756
)
Mean corpuscular hemoglobin concentration (
29403010
)
Diverticular disease (
30177863
)
Interacting Genes
44 interacting genes:
BTK
CD93
CISH
FADD
FLII
IKBKG
IL1R1
IL1RAP
IL1RL1
IRAK1
IRAK2
IRAK3
IRAK4
IRF4
IRF5
IRF7
MAL
MBIP
MDM2
NTAQ1
PELI2
PFKL
POLR1C
PRDX1
RAC1
RNF152
RNF4
SARM1
SIAH2
SMAD3
SPOP
SPOPL
STAP2
TIRAP
TLR10
TLR2
TLR3
TLR4
TLR5
TLR7
TLR8
TXN
USP7
ZNF35
54 interacting genes:
ABCA1
ANK3
ATG5
BTG1
CASP10
CASP8
CASP8AP2
CFLAR
CSNK1A1
DAP3
DAPK1
DDIT4L
DDX24
DEDD
EDA2R
FAF1
FAS
FASLG
HIPK3
IKBKG
IRAK1
LRRCC1
MBD4
MKRN1
MOB4
MYD88
NACA
NOL3
NUTM2F
PARK7
PEA15
PIDD1
PIN1
PRKCZ
PTPN13
RALBP1
RAP1A
RIPK1
RNF4
RYBP
SDCBP
STAT1
STUB1
TAB1
TCEA2
TNFRSF10A
TNFRSF10B
TRADD
TRAF2
TRIM21
UBE2I
XPO5
ZCCHC12
ZMYM5
Entrez ID
4615
8772
HPRD ID
03703
03909
Ensembl ID
ENSG00000172936
ENSG00000168040
Uniprot IDs
A0A0A0MSI9
A0A3B3ITY3
A0A3F2YP85
Q99836
Q13158
PDB IDs
2JS7
2Z5V
3MOP
4DOM
4EO7
6I3N
1A1W
1A1Z
1E3Y
1E41
2GF5
3EZQ
3OQ9
6ACI
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?