MVD and EIF4EBP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		MVD	EIF4EBP1
Description		mevalonate diphosphate decarboxylase	eukaryotic translation initiation factor 4E binding protein 1
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GO Annotations	Cellular Component	Peroxisome Cytosol	Nucleus Cytoplasm Cytosol Protein-containing Complex Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Diphosphomevalonate Decarboxylase Activity ATP Binding Hsp70 Protein Binding Protein Homodimerization Activity	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity Protein Phosphatase 2A Binding
	Biological Process	Cholesterol Biosynthetic Process Positive Regulation Of Cell Population Proliferation Isoprenoid Biosynthetic Process Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Lung Development Negative Regulation Of Protein-containing Complex Assembly TOR Signaling Response To Ethanol Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation Cellular Response To Hypoxia Response To Amino Acid Starvation
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP) Synthesis of Dolichyl-phosphate	mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Drugs
Diseases
GWAS		Feeling fed-up ( 29500382) Hair color ( 26926045)	Menopause (age at onset) ( 29773799)
Interacting Genes		6 interacting genes: BTAF1 EEF1G EIF4EBP1 GNB5 HSPA9 TUBB3	41 interacting genes: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 DDIT4L EIF4E EIF4E1B EIF4E2 FGFR1 GSK3B IRAK4 LATS1 LMO2 LRRK2 MAPK1 MAPK14 MAPKAPK5 MEOX1 MLST8 MTOR MVD NRG1 PICK1 PLAT POU6F2 PPP2CA PRKCA PRKDC PTPA REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4 ZNF655
Entrez ID		4597	1978
HPRD ID		04454	03746
Ensembl ID		ENSG00000167508	ENSG00000187840
Uniprot IDs		P53602	Q13541
PDB IDs		3D4J	1EJ4 1EJH 1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X 4UED 5BXV 5EKV 5NVN 5WBJ 6BCU 6BCX
Enriched GO Terms of Interacting Partners?
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