MUTYH and RPA4

Number of citations of the paper that reports this interaction (PubMedID 11092888)
70

Data Source:
HPRD (in vitro, in vivo)

		MUTYH	RPA4
Description		mutY DNA glycosylase	replication protein A4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break
	Molecular Function	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Protein Binding DNA N-glycosylase Activity Oxidized Purine DNA Binding MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Adenine/guanine Mispair Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Single-stranded DNA Binding Protein Binding
	Biological Process	DNA Repair Base-excision Repair Mismatch Repair Depurination	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Replication Initiation Nucleotide-excision Repair Nuclear DNA Replication
Pathways			Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Composite immunoglobulin trait (IgA/IgM) ( 28628107) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		20 interacting genes: AGTRAP APEX1 BAAT CYLC2 FANCC HRAS LMNA LRSAM1 MSANTD3 MSH6 PCNA RPA1 RPA4 SEC61B SIRT6 SMAD1 TDRD7 TNFRSF9 TSTD2 XPA	8 interacting genes: APP MSH2 MSH3 MUTYH PTRHD1 RPA1 RPA3 XPA
Entrez ID		4595	29935
HPRD ID		05380	06591
Ensembl ID		ENSG00000132781	ENSG00000204086
Uniprot IDs		D3DPZ6 E5KP25 E5KP26 E5KP27 E5KP28 E9PM53 Q9UIF7	Q13156
PDB IDs		1X51 3N5N
Enriched GO Terms of Interacting Partners?
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