MTRR and GFER

		MTRR	GFER
Description		5-methyltetrahydrofolate-homocysteine methyltransferase reductase	growth factor, augmenter of liver regeneration
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Intermediate Filament Cytoskeleton	Extracellular Region Mitochondrion Mitochondrial Intermembrane Space Cytosol
	Molecular Function	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase Activity Flavin Adenine Dinucleotide Binding NADPH Binding FAD Binding	Protein Binding Growth Factor Activity Protein-disulfide Reductase Activity Flavin-linked Sulfhydryl Oxidase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	DNA Methylation Methionine Biosynthetic Process S-adenosylmethionine Cycle Homocysteine Catabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process Negative Regulation Of Cystathionine Beta-synthase Activity	Liver Development Signal Transduction
Pathways		Methylation Sulfur amino acid metabolism Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	Mitochondrial protein import
Drugs		Cyanocobalamin Methionine	Flavin adenine dinucleotide
Diseases
GWAS		Capecitabine sensitivity ( 22864933) Hyperinsulinemia in lower physical activity ( 30327367) Metabolite levels ( 23823483) Verbal declarative memory ( 25648963)
Interacting Genes		3 interacting genes: GFER GMCL1 MMAB	11 interacting genes: ASCC2 BNIPL COPS2 COPS5 METTL9 MTRR NPIPA1 PLEKHF2 SMAD2 TXN YY1
Entrez ID		4552	2671
HPRD ID		03979	02954
Ensembl ID		ENSG00000124275	ENSG00000127554
Uniprot IDs		Q9UBK8	P55789
PDB IDs		2QTL 2QTZ	3MBG 3O55 3TK0 3U2L 3U2M 3U5S 4LDK
Enriched GO Terms of Interacting Partners?
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