MSN and PLEC

Number of citations of the paper that reports this interaction (PubMedID 11441066)
4

Data Source:
HPRD (in vivo)

		MSN	PLEC
Description		moesin	plectin
Image
GO Annotations	Cellular Component	Uropod Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Focal Adhesion Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Filopodium Pseudopodium Microvillus Membrane Vesicle Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Blood Microparticle	Cytoplasm Mitochondrial Outer Membrane Cytosol Intermediate Filament Plasma Membrane Brush Border Focal Adhesion Membrane Sarcoplasm Z Disc Hemidesmosome Axon Dendrite Sarcolemma Costamere Myelin Sheath Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Double-stranded RNA Binding Actin Binding Signaling Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein Kinase Binding Cell Adhesion Molecule Binding	Dystroglycan Binding RNA Binding Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Ankyrin Binding Protein Self-association Cadherin Binding
	Biological Process	Immunological Synapse Formation Cytoskeleton Organization Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Gland Morphogenesis Membrane To Membrane Docking T Cell Proliferation Establishment Of Epithelial Cell Apical/basal Polarity Leukocyte Migration Establishment Of Endothelial Barrier T Cell Aggregation Cellular Response To Testosterone Stimulus Positive Regulation Of Podosome Assembly T Cell Migration Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport	Cell Morphogenesis Leukocyte Migration Involved In Immune Response Keratinocyte Development Negative Regulation Of Protein Kinase Activity Nucleus Organization Gene Expression Fibroblast Migration T Cell Chemotaxis Skeletal Myofibril Assembly Transmission Of Nerve Impulse Respiratory Electron Transport Chain Actin Cytoskeleton Reorganization Hemidesmosome Assembly Cellular Response To Extracellular Stimulus Response To Food Peripheral Nervous System Myelin Maintenance Adherens Junction Organization Cellular Protein Localization Multicellular Organism Growth Wound Healing Regulation Of Vascular Permeability Protein-containing Complex Subunit Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Sarcomere Organization Myoblast Differentiation Skeletal Muscle Fiber Development Cardiac Muscle Cell Development Establishment Of Skin Barrier Mitochondrion Morphogenesis Cellular Response To Mechanical Stimulus Cellular Response To Hydrostatic Pressure Cellular Response To Fluid Shear Stress Tight Junction Organization Actomyosin Contractile Ring Assembly Actin Filament Organization Regulation Of ATP Citrate Synthase Activity
Pathways		Recycling pathway of L1 Recycling pathway of L1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Signaling by ALK fusions and activated point mutants	Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins Type I hemidesmosome assembly
Drugs
Diseases
GWAS		Male-pattern baldness ( 28196072)	Anti-saccade response ( 29064472) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fibrinogen levels ( 28107422 26561523) Haemorrhoidal disease ( 33888516) Height ( 31562340) Hip index ( 34021172) Knee osteoarthritis ( 28916551) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Left ventricular ejection fraction (MTAG) ( 33495596) Left ventricular global radial strain (MTAG) ( 33495596) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosquito bite size ( 28199695) Periodontitis (stage III/IV grade C) ( 33745150) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624) Total cholesterol levels ( 30275531)
Interacting Genes		33 interacting genes: BCAP31 CD44 CD46 CD93 CDK11B CFC1 ERBB2 EZR ICAM1 ICAM2 ICAM3 L1CAM LINC01554 LMO2 MYBPC2 NCF1 NCF4 PLEC PPM1A PPM1B PRKAR2A PRKCQ ROCK1 SELL SELPLG SLC9A3R1 SMURF1 SPN TERF1 TRIM15 TSC1 VCAM1 VPS11	24 interacting genes: ACTC1 ACTG1 ANK3 BRCA2 CASP8 CDK1 COL17A1 EGFR ITGA6 ITGB4 LMNB1 MAP2 MSN MTDH PLEKHA5 PTEN RACK1 SMAD9 SNAPIN SPTA1 SPTAN1 SUMO2 UBC VIM
Entrez ID		4478	5339
HPRD ID		02399	03180
Ensembl ID		ENSG00000147065	ENSG00000178209
Uniprot IDs		P26038 V9HWC0	Q15149
PDB IDs		1E5W 1EF1 1SGH 6TXQ 6TXS	1MB8 2N03 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO 4Q58 4Q59 5J1F 5J1G 5J1H 5J1I
Enriched GO Terms of Interacting Partners?
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