MAP1LC3C and AMBRA1

Number of citations of the paper that reports this interaction (PubMedID 30217973)
58

Data Source:
BioGRID (unspecified method)

		MAP1LC3C	AMBRA1
Description		microtubule associated protein 1 light chain 3 gamma	autophagy and beclin 1 regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Autophagosome Cytosol Microtubule Endomembrane System Organelle Membrane Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Cytosol Axoneme Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding	Protein Binding Ubiquitin Protein Ligase Binding GTPase Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Protein Exit From Endoplasmic Reticulum Aggrephagy Autophagosome Maturation	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Nervous System Development Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Mitochondrial Depolarisation
Pathways		Macroautophagy	Macroautophagy
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Metabolite levels ( 23823483)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Immunoglobulin A ( 20694011) Insulin-related traits (multivariate analysis) ( 32002517) Normal facial asymmetry (angle of deformation score) ( 30631343) Schizophrenia ( 28991256 29483656 30285260) Selective IgA deficiency ( 27723758)
Interacting Genes		32 interacting genes: AMBRA1 ANK2 ANK3 ATG13 ATXN3 CALCOCO2 CAPN3 CUL3 GMEB2 IRGM KBTBD6 KBTBD7 LAT LMNB1 MEFV MISP NEDD4 OPRM1 OPTN RHOXF1 RUFY4 STK3 TAX1BP1 TBC1D25 TNIP1 TP53INP1 TRIM21 TRIM32 TSR2 WDFY3 WDR81 ZNF24	20 interacting genes: ALX4 BECN1 CHUK CREM CUL4B GABARAP GABARAPL1 GABARAPL2 HSD17B12 KBTBD4 MAP1LC3A MAP1LC3B MAP1LC3C MTCH2 MTOR PEX11A RNF2 SLC35C1 SNCA UBE2D3
Entrez ID		440738	55626
HPRD ID		14226	10975
Ensembl ID		ENSG00000197769	ENSG00000110497
Uniprot IDs		Q9BXW4	A0A075B6T1 Q9C0C7
PDB IDs		2NCN 3VVW 3WAM 3WAP 5DPW
Enriched GO Terms of Interacting Partners?
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