CCDC88C and TAFAZZIN

		CCDC88C	TAFAZZIN
Description		coiled-coil domain containing 88C	tafazzin, phospholipid-lysophospholipid transacylase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cell Junction	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Membrane
	Molecular Function	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity Frizzled Binding Protein Binding Microtubule Binding PDZ Domain Binding Identical Protein Binding Protein Self-association Dynein Light Intermediate Chain Binding	1-acylglycerol-3-phosphate O-acyltransferase Activity O-acyltransferase Activity 1-acylglycerophosphocholine O-acyltransferase Activity
	Biological Process	Regulation Of Protein Phosphorylation Apical Constriction Small GTPase Mediated Signal Transduction Cytoskeleton-dependent Intracellular Transport Stress-activated Protein Kinase Signaling Cascade Cytoplasmic Microtubule Organization Protein Destabilization Non-canonical Wnt Signaling Pathway Regulation Of Catalytic Activity Negative Regulation Of Canonical Wnt Signaling Pathway	Mitophagy Heart Morphogenesis Muscle Contraction Mitochondrion Organization Inner Mitochondrial Membrane Organization Heart Development Skeletal Muscle Tissue Development Hemopoiesis Cardiolipin Metabolic Process Cardiolipin Biosynthetic Process Mitochondrial Respiratory Chain Complex I Assembly Cardiolipin Acyl-chain Remodeling Cristae Formation Mitochondrial ATP Synthesis Coupled Electron Transport Spermatocyte Division Cardiac Muscle Tissue Development Cardiac Muscle Contraction Positive Regulation Of Cardiolipin Metabolic Process Positive Regulation Of ATP Biosynthetic Process
Pathways		Negative regulation of TCF-dependent signaling by DVL-interacting proteins	Mitochondrial protein import Mitochondrial protein import Acyl chain remodeling of CL
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Daytime sleep phenotypes ( 27126917) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		8 interacting genes: APP DVL1 FBXO7 GNAI3 ITSN2 MAPK8 TAFAZZIN TSC22D1	16 interacting genes: BTRC CCDC88C CHGB CSNK1E GSK3B LATS1 LATS2 OPN1LW RPL10 RUNX1 SLC6A8 SLC9A3R2 SSR4 TRAK2 VBP1 YWHAE
Entrez ID		440193	6901
HPRD ID		19136	02316
Ensembl ID		ENSG00000015133	ENSG00000102125
Uniprot IDs		B4DZB8 Q9P219	A0A0S2Z4E6 A0A0S2Z4F4 A0A0S2Z4K0 A0A0S2Z4K9 A0A494C0C5 A0A499FJ53 A6XNE1 Q16635
PDB IDs
Enriched GO Terms of Interacting Partners?
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