MPL and THPO

Number of citations of the paper that reports this interaction (PubMedID 9766811)
6

Data Source:
HPRD (in vivo)

		MPL	THPO
Description		MPL proto-oncogene, thrombopoietin receptor	thrombopoietin
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Membrane Neuron Projection Neuronal Cell Body	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Thrombopoietin Receptor Activity	Signaling Receptor Binding Cytokine Activity Hormone Activity Growth Factor Activity
	Biological Process	Neutrophil Homeostasis Monocyte Homeostasis Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Platelet Aggregation Cellular Response To Hypoxia Positive Regulation Of Platelet Formation Eosinophil Homeostasis Basophil Homeostasis	Positive Regulation Of Protein Phosphorylation Multicellular Organism Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Megakaryocyte Development Thrombopoietin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Receptor Signaling Pathway Via STAT Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		Platelet Aggregation (Plug Formation)	Platelet Aggregation (Plug Formation)
Drugs		Romiplostim SB-559448 Eltrombopag Thrombopoietin Avatrombopag Lusutrombopag
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Cardiometabolic and hematological traits ( 27668658) Diisocyanate-induced asthma ( 25918132) Mean spheric corpuscular volume ( 32888494) Platelet count ( 22139419 29403010 32888494 20139978 27863252) Plateletcrit ( 32888494 27863252)
Interacting Genes		10 interacting genes: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 PTPRF SHC1 SOCS1 THPO YWHAQ	4 interacting genes: APH1A EP300 MPL NUMBL
Entrez ID		4352	7066
HPRD ID		01161	02500
Ensembl ID		ENSG00000117400	ENSG00000090534
Uniprot IDs		P40238	A0A3B3ITS0 F8W6L1 P40225 Q5FBX8
PDB IDs			1V7M 1V7N
Enriched GO Terms of Interacting Partners?
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