CD200 and CASR

		CD200	CASR
Description		CD200 molecule	calcium sensing receptor
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Axon Neuron Projection Neuronal Cell Body Cell Body	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Neuronal Cell Body Axon Terminus
	Molecular Function	Protein Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion Glycosylated Region Protein Binding	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Integrin Binding Calcium Ion Binding Protein Binding Amino Acid Binding Protein Kinase Binding Protein Homodimerization Activity Transmembrane Transporter Binding
	Biological Process	Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Population Proliferation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Positive Regulation Of CREB Transcription Factor Activity Heterotypic Cell-cell Adhesion Negative Regulation Of Macrophage Activation Regulation Of Immune Response Positive Regulation Of Transforming Growth Factor Beta Production Cell-cell Adhesion Positive Regulation Of Arginase Activity Positive Regulation Of Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Neuron Death Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Macrophage Migration Negative Regulation Of T Cell Migration	Ossification Response To Ischemia Detection Of Calcium Ion Cellular Calcium Ion Homeostasis Apoptotic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway JNK Cascade Chemosensory Behavior Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Positive Regulation Of ATPase Activity Bile Acid Secretion Cellular Response To Hepatocyte Growth Factor Stimulus Vasodilation Positive Regulation Of Vasoconstriction Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Positive Chemotaxis Regulation Of Calcium Ion Transport Fat Pad Development Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Import Cellular Response To Vitamin D Cellular Response To Glucose Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hypoxia Response To Fibroblast Growth Factor Positive Regulation Of Calcium Ion Import Cellular Response To Peptide Chloride Transmembrane Transport
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	G alpha (q) signalling events G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			Spermine Neomycin Cinacalcet Ronacaleret NPS-2143 Calcium citrate Calcium Phosphate Etelcalcetide Calcium phosphate dihydrate
Diseases
GWAS		Basal cell carcinoma ( 33549134) Blood protein levels ( 30072576) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)	Calcium levels ( 20661308 25972035 25886283 24068962 29403010 20705733) Cardiac Troponin-T levels ( 23247143) Chronic widespread musculoskeletal pain ( 33331911) Clinical laboratory measurements ( 27897004) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Kidney stones ( 26272126) Metabolite levels ( 31628463) Phosphorus levels ( 20558539) Psoriasis ( 25854761) QT interval ( 29874175) Serum parathyroid hormone levels ( 27927781) Type 2 diabetes ( 32499647 30718926)
Interacting Genes		10 interacting genes: CASR CD200R1 CFAP91 HCRTR2 HUS1 MAST2 PLOD1 TMEM11 TMEM147 ZNF652	13 interacting genes: CD200 FLNA GRM1 HIF1A NOTCH1 PI4K2B PRKCA PRKCB PRKCG RNF19A STAMBP TCF4 VHL
Entrez ID		4345	846
HPRD ID		01124	03122
Ensembl ID		ENSG00000091972	ENSG00000036828
Uniprot IDs		B4DDZ6 F8W7G1 P41217	P41180
PDB IDs			5FBH 5FBK 5K5S 5K5T
Enriched GO Terms of Interacting Partners?
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