CD200 and CD200R1

Number of citations of the paper that reports this interaction (PubMedID 12960329)
146

Data Source:
HPRD (in vivo, in vitro)

		CD200	CD200R1
Description		CD200 molecule	CD200 receptor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Axon Neuron Projection Neuronal Cell Body Cell Body	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex
	Molecular Function	Protein Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion Glycosylated Region Protein Binding	Protein Binding Immunoglobulin Receptor Activity Signaling Receptor Activity Glycosylated Region Protein Binding
	Biological Process	Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Population Proliferation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Positive Regulation Of CREB Transcription Factor Activity Heterotypic Cell-cell Adhesion Negative Regulation Of Macrophage Activation Regulation Of Immune Response Positive Regulation Of Transforming Growth Factor Beta Production Cell-cell Adhesion Positive Regulation Of Arginase Activity Positive Regulation Of Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Neuron Death Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Macrophage Migration Negative Regulation Of T Cell Migration	Signal Transduction Negative Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Neuron Death Negative Regulation Of Macrophage Migration Negative Regulation Of T Cell Migration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Basal cell carcinoma ( 33549134) Blood protein levels ( 30072576) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)	Asthma ( 32296059) Blood protein levels ( 30072576 29875488) Economic and political preferences ( 22566634) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neurological blood protein biomarker levels ( 31320639) Rheumatoid arthritis ( 28118524) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		10 interacting genes: CASR CD200R1 CFAP91 HCRTR2 HUS1 MAST2 PLOD1 TMEM11 TMEM147 ZNF652	9 interacting genes: ADIPOQ CD200 CLDN19 ERMP1 GALNT15 NINJ1 PTCH1 SFTPC SGTB
Entrez ID		4345	131450
HPRD ID		01124	09609
Ensembl ID		ENSG00000091972	ENSG00000163606
Uniprot IDs		B4DDZ6 F8W7G1 P41217	Q8TD46
PDB IDs
Enriched GO Terms of Interacting Partners?
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