ACAN and MAN2A2

		ACAN	MAN2A2
Description		aggrecan	mannosidase alpha class 2A member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix	Golgi Membrane Integral Component Of Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding	Alpha-mannosidase Activity Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Carbohydrate Binding Metal Ion Binding
	Biological Process	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development	Mannose Metabolic Process Protein Glycosylation N-glycan Processing Protein Deglycosylation
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Intra-Golgi traffic Reactions specific to the complex N-glycan synthesis pathway
Drugs		Ilomastat
Diseases
GWAS		Age-related hearing impairment ( 27764096) Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Dupuytren's disease ( 28886342) Height ( 21998595 28552196 20881960 25282103 25133637 25429064 23563607 31562340 28270201 18391952 33713608) Hip circumference adjusted for BMI ( 34021172 25673412) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500)	Attention deficit hyperactivity disorder ( 18839057) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee ( 33287642) Schizophrenia ( 25056061 29483656)
Interacting Genes		23 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 BLM CTSB FBLN1 FBLN2 HAPLN1 IDH2 LUM MAN2A2 MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF SLCO3A1 STARD5 TNFAIP6 TNR	8 interacting genes: ACAN CHD3 ELP1 ENO3 FES GIT1 LUC7L2 VIM
Entrez ID		176	4122
HPRD ID		01123	02994
Ensembl ID		ENSG00000157766	ENSG00000196547
Uniprot IDs		A0A5K1VW97 P16112	P49641
PDB IDs		4MD4
Enriched GO Terms of Interacting Partners?
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