Description |
mitogen-activated protein kinase kinase kinase 1 |
actinin alpha 1 |
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GO Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
- Alanine aminotransferase levels ( 33547301 33339817)
- Alanine transaminase levels ( 29403010)
- Blond vs. brown/black hair color ( 30531825)
- Body shape index ( 34021172)
- Brain morphology (MOSTest) ( 32665545)
- Breast cancer ( 29059683 17529967 23535729 31757997 20453838 19330030)
- Breast cancer (early onset) ( 24493630)
- Brown vs. black hair color ( 30531825)
- Coronary artery disease ( 29212778)
- Cortical surface area (MOSTest) ( 32665545)
- Fasting blood insulin ( 25631608)
- Fasting glucose in pregnancy (gestational week 14-16) ( 30324795)
- Fasting insulin ( 33402679)
- Fasting insulin (dietary factor interaction) ( 24204828)
- Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828)
- Initial pursuit acceleration ( 29064472)
- Lung function (FEV1) ( 30061609)
- Refractive error ( 32231278)
- Serum alkaline phosphatase levels ( 33547301)
- Sexual dimorphism in anthropometric traits ( 23754948)
- Subcortical volume (MOSTest) ( 32665545)
- Triglyceride levels ( 28334899 32902719)
- Triglycerides ( 24097068 20686565)
- Type 2 diabetes ( 23209189)
- Urate levels (BMI interaction) ( 25811787)
- Waist circumference ( 23966867)
- Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
- Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist circumference adjusted for BMI in active individuals ( 28448500)
- Waist circumference adjusted for BMI in non-smokers ( 28443625)
- Waist circumference adjusted for body mass index ( 25673412 28448500)
- Waist-hip index ( 34021172)
- Waist-hip ratio ( 25673412)
- Waist-to-hip ratio adjusted for BMI ( 34021172 26426971)
- Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971)
- Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
- Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist-to-hip ratio adjusted for BMI (smoking interaction) ( 28443625)
- Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500)
- Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
- Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
- Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
- White matter hyperintensity volume ( 33293549)
- White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
- White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
- Youthful appearance (self-reported) ( 32339537)
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Interacting Genes |
97 interacting genes:
ACTN1
APEX2
APPL1
ARHGAP4
ASCC2
ATXN3
BAALC
BAP1
BRCA1
CARD14
CCDC69
CD74
CEP85
CHRM5
CHUK
COPS6
CRELD1
CRTC1
CUEDC1
DCUN1D1
DCUN1D2
DENND6B
DNAJB2
DNAJB6
DTX1
EPHA1
EPN1
FAF2
FAM184A
FKBP6
GGA2
GRIPAP1
GSK3B
HBS1L
HGS
HIP1
IKBKB
ILRUN
IMPACT
KRT36
MAP2K4
MAP2K7
MAPK1
MAPK9
MBP
MINDY3
NEK10
NFKBIA
NOTCH1
NPLOC4
NR4A1
ODF2
PAK1
PLEKHB2
PSMD4
RAB3IL1
RABEP2
RAD18
RAD23A
RAD51AP1
RAF1
RBCK1
RIPK1
RNF114
RNF126
RNF141
SPART
STAM
STAM2
TAB1
TNIP1
TOM1
TOM1L2
TP53
TRAF2
UBAC1
UBAP1
UBASH3B
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2G1
UBE2I
UBE2K
UBE2L6
UBE2V1
UBE2W
UBQLN1
UBXN7
UCHL5
UFD1
USP28
YWHAE
ZFAND3
ZFAND5
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92 interacting genes:
ACTN2
ACTN3
ADORA2A
APC
APPBP2
ATXN2
ATXN7
C14orf119
CACNA1A
CAMK2A
CBY2
CDK5
CDK5R1
CDK5R2
CLIC5
COIL
COL17A1
CSRP1
CSRP3
CTNNA1
DDIAS
DYNLT1
EIF2S1
EPM2AIP1
ERBIN
FBP1
FXN
FXR1
GADD45G
GFI1B
GIPC1
GIT2
GRIA4
GRIN2A
GRM5
GTF2H1
HSPB1
ICAM5
ITGB1
KAT2B
KCTD6
KPNA2
LINC01554
LNX1
LPP
MAGEA11
MAP2
MAP3K1
MED14
MICALL2
MTDH
MTNR1A
MTNR1B
MYOT
MYOZ1
MYOZ2
MYOZ3
NEBL
NKAPD1
NR1H3
NUMBL
OAS1
PALLD
PDHX
PDLIM1
PDLIM5
PIAS4
PKD1
PKN1
PLD2
PSEN1
PSMA1
PTK2
PTPN1
PTPN6
PYGB
RAVER1
RPS27
SIRPA
SLC2A4
SORBS2
SRC
SSX2IP
SYNPO2L
TES
TSC1
TTN
TXN
USP2
VCL
XRCC4
ZYX
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Entrez ID |
4214 |
87 |
HPRD ID |
19599 |
00020 |
Ensembl ID |
ENSG00000095015
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ENSG00000072110
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Uniprot IDs |
Q13233
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A0A024R694
A0A7I2V4Y4
P12814
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PDB IDs |
6WHB
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2EYI
2EYN
2N8Y
2N8Z
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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