MC2R and MRAP2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		MC2R	MRAP2
Description		melanocortin 2 receptor	melanocortin 2 receptor accessory protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Corticotropin Receptor Activity Protein Binding	Protein Binding Signaling Receptor Regulator Activity Corticotropin Hormone Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 5 Melanocortin Receptor Binding Identical Protein Binding Type 1 Melanocortin Receptor Binding
	Biological Process	Placenta Development G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Regulation Of Metabolic Process	Energy Reserve Metabolic Process Feeding Behavior Protein Localization To Plasma Membrane Energy Homeostasis Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events Defective ACTH causes obesity and POMCD ADORA2B mediated anti-inflammatory cytokines production
Drugs		Tetracosactide Corticotropin Seractide acetate Bremelanotide
Diseases
GWAS		Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Negative urgency ( 30718321) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)	Schizophrenia ( 28991256) Whole brain grey matter density ( 31530798)
Interacting Genes		4 interacting genes: ASIP MRAP MRAP2 POMC	6 interacting genes: APH1A APP ISLR2 MC2R SGTA TMEM80
Entrez ID		4158	112609
HPRD ID		06304	12843
Ensembl ID		ENSG00000185231	ENSG00000135324
Uniprot IDs		Q01718	Q96G30
PDB IDs
Enriched GO Terms of Interacting Partners?
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