MRAP2 and MC2R

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		MRAP2	MC2R
Description		melanocortin 2 receptor accessory protein 2	melanocortin 2 receptor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Signaling Receptor Regulator Activity Corticotropin Hormone Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 5 Melanocortin Receptor Binding Identical Protein Binding Type 1 Melanocortin Receptor Binding	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Corticotropin Receptor Activity Protein Binding
	Biological Process	Energy Reserve Metabolic Process Feeding Behavior Protein Localization To Plasma Membrane Energy Homeostasis Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane	Placenta Development G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Regulation Of Metabolic Process
Pathways			Peptide ligand-binding receptors G alpha (s) signalling events Defective ACTH causes obesity and POMCD ADORA2B mediated anti-inflammatory cytokines production
Drugs			Tetracosactide Corticotropin Seractide acetate Bremelanotide
Diseases
GWAS		Schizophrenia ( 28991256) Whole brain grey matter density ( 31530798)	Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Negative urgency ( 30718321) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
Interacting Genes		6 interacting genes: APH1A APP ISLR2 MC2R SGTA TMEM80	4 interacting genes: ASIP MRAP MRAP2 POMC
Entrez ID		112609	4158
HPRD ID		12843	06304
Ensembl ID		ENSG00000135324	ENSG00000185231
Uniprot IDs		Q96G30	Q01718
PDB IDs
Enriched GO Terms of Interacting Partners?
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