MBD1 and NELL1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		MBD1	NELL1
Description		methyl-CpG binding domain protein 1	neural EGFL like 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck	Extracellular Region Nuclear Envelope Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Unmethylated CpG Binding	Protein Kinase C Binding Calcium Ion Binding Protein Binding Heparin Binding
	Biological Process	Transcription By RNA Polymerase II Heart Development Aging Response To Xenobiotic Stimulus Negative Regulation Of Gene Expression Neuron Differentiation Response To Nutrient Levels Response To Estradiol Response To Cocaine Regulation Of DNA Methylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Astrocyte Differentiation	Nervous System Development Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Bone Mineralization Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Cellular Protein Catabolic Process
Pathways		SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464)	Adverse response to lamotrigine and phenytoin ( 22379998) Attention function in attention deficit hyperactive disorder ( 26174813) Blood protein levels ( 29875488) Bone mineral density change response to combined chemotherapy in acute lymphoblastic leukemia ( 29266176) Cannabis use (initiation) ( 22823124) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Crohn's disease ( 17684544) Fibrinogen levels (smoking status, alcohol consumption or body mass index interaction) ( 25551457) Hepcidin levels ( 27846281) Hepcidin/transferrin saturation ratio ( 27846281) Hippocampal sclerosis ( 25188341) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Prudent dietary pattern ( 28644415) Response to amphetamines ( 22952603) Response to long-chain n-3 polyunsaturated fatty acid supplementation (change in triglyceride levels) ( 24847101) Triglyceride levels in HIV infection ( 33109212) Weight ( 28552196)
Interacting Genes		45 interacting genes: APP ATF7IP ATF7IP2 ATXN1L C1QBP CBX4 CBX5 CCDC136 CHAF1A COPE DVL3 ECT2 EEF1G GRN HDAC3 HIPK3 HTT JAG2 LTBP3 LTBP4 MDFI MEGF6 NELL1 NELL2 NOTCH1 NOTCH3 OASL PIAS1 PIAS2 POMGNT1 RNF2 SETDB1 SLC25A3 SMAD1 SMAD3 SMAD5 SMAD7 SMAD9 SNAPC2 SP1 SUV39H1 TENM1 TNC ZNF384 ZNF512B	8 interacting genes: ATN1 ATXN7 CACNA1A GFI1B HOXA1 MBD1 MEOX2 NUFIP2
Entrez ID		4152	4745
HPRD ID		01133	09081
Ensembl ID		ENSG00000141644	ENSG00000165973
Uniprot IDs		A8K654 B4DI41 B4DUR3 Q9UIS9	B3KXR2 F5H6I3 J3KNC5 K9UUD5 Q92832
PDB IDs		1D9N 1IG4 4D4W 5W9Q 6D1T	6POL
Enriched GO Terms of Interacting Partners?
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