MAF and NEU1

		MAF	NEU1
Description		MAF bZIP transcription factor	neuraminidase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Specific Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Sequence-specific Double-stranded DNA Binding	Exo-alpha-sialidase Activity Protein Binding Alpha-sialidase Activity Exo-alpha-(2->3)-sialidase Activity Exo-alpha-(2->6)-sialidase Activity Exo-alpha-(2->8)-sialidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Inner Ear Development Lens Fiber Cell Differentiation	Ganglioside Catabolic Process Oligosaccharide Catabolic Process
Pathways		RUNX2 regulates osteoblast differentiation	Glycosphingolipid metabolism Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation
Drugs			Oseltamivir
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Alzheimer's disease (late onset) ( 30820047) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Colorectal cancer ( 30529582 31826910) Depressive symptoms (SSRI exposure interaction) ( 25649181) Estimated glomerular filtration rate ( 31015462) Height ( 20668459) High density lipoprotein cholesterol levels ( 33339817) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lysophosphatidylcholine levels ( 31551469) Macular thickness ( 30535121) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244 24076602 21833088) Obesity ( 19151714) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Refractive error ( 32231278) Renal function-related traits (urea) ( 22797727) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Serum alkaline phosphatase levels ( 33547301 29403010 33339817) Serum thyroid-stimulating hormone levels ( 24852370) Serum uric acid levels ( 30993211) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335) Thyroid volume ( 21565293) Triglyceride levels ( 32203549) Urate levels ( 31985003 23263486) Vitamin C levels ( 33203707)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Blood protein levels ( 28240269) Body shape index ( 34021172) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172)
Interacting Genes		17 interacting genes: ATF4 CREBBP EP300 ETS1 FOS FOSL1 HOXD12 JUN MAFA MAFB MAFG MYB NEU1 SMARCA5 SOX9 UBE2O USF2	37 interacting genes: AQP6 CCR9 CD79A CDC42SE2 CERS3 CERS4 CREB3 CREB3L1 CTSA EBP EEF1A1 ERGIC3 ERRFI1 GLB1 GOLM1 GPR152 GPX8 HSD17B11 IGF1 JUNB KCNA2 KCNA4 LIG4 LMNA MAF MGST3 MSH5 MUC1 NFYA NOTCH4 PBX2 SLC10A1 SLC10A6 SLC17A2 SLC18A1 SLC39A9 TMEM14B
Entrez ID		4094	4758
HPRD ID		01518	09751
Ensembl ID		ENSG00000178573	ENSG00000204386
Uniprot IDs		H3BP11 O75444	Q5JQI0 Q99519
PDB IDs
Enriched GO Terms of Interacting Partners?
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