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SMAD4 and ATF2
Number of citations of the paper that reports this interaction (PubMedID
10085140
)
76
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
SMAD4
ATF2
Description
SMAD family member 4
activating transcription factor 2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Activin Responsive Factor Complex
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Outer Membrane
Site Of Double-strand Break
H4 Histone Acetyltransferase Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Collagen Binding
Identical Protein Binding
Protein Homodimerization Activity
Sulfate Binding
Sequence-specific DNA Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
I-SMAD Binding
R-SMAD Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Histone Acetyltransferase Activity
Protein Binding
CAMP Response Element Binding Protein Binding
H4 Histone Acetyltransferase Activity
Protein Kinase Binding
CAMP Response Element Binding
Identical Protein Binding
H2B Histone Acetyltransferase Activity
Protein-containing Complex Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ovarian Follicle Development
Branching Involved In Ureteric Bud Morphogenesis
Response To Hypoxia
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Outflow Tract Septum Morphogenesis
Cardiac Conduction System Development
Atrioventricular Valve Formation
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Left Ventricular Cardiac Muscle Tissue Morphogenesis
Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Brainstem Development
Regulation Of Transcription By RNA Polymerase II
Cellular Iron Ion Homeostasis
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Spermatogenesis
Single Fertilization
Axon Guidance
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Neural Crest Cell Differentiation
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Differentiation
Negative Regulation Of Cell Growth
BMP Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Somite Rostral/caudal Axis Specification
Regulation Of Transforming Growth Factor Beta2 Production
Positive Regulation Of Luteinizing Hormone Secretion
Intracellular Signal Transduction
Atrioventricular Canal Development
Endothelial Cell Activation
Embryonic Digit Morphogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Follicle-stimulating Hormone Secretion
Mesendoderm Development
Developmental Growth
Neuron Fate Commitment
Sebaceous Gland Development
Formation Of Anatomical Boundary
Regulation Of Binding
Positive Regulation Of Histone H3-K4 Methylation
Regulation Of Hair Follicle Development
Uterus Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Negative Regulation Of Cell Death
Endocardial Cell Differentiation
Female Gonad Morphogenesis
Secondary Palate Development
Interleukin-6-mediated Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Response To Transforming Growth Factor Beta
Cellular Response To BMP Stimulus
Metanephric Mesenchyme Morphogenesis
Nephrogenic Mesenchyme Morphogenesis
Seminiferous Tubule Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Cardiac Myofibril Assembly
Positive Regulation Of Histone H3-K9 Acetylation
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
NK T Cell Differentiation
Liver Development
Positive Regulation Of Protein Phosphorylation
Hematopoietic Progenitor Cell Differentiation
Outflow Tract Morphogenesis
Brainstem Development
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Response To Osmotic Stress
Cellular Response To DNA Damage Stimulus
Vacuole Organization
JNK Cascade
Response To Water Deprivation
Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Angiogenesis
Abducens Nucleus Development
Hypoglossal Nucleus Development
Facial Nucleus Development
Mitotic Intra-S DNA Damage Checkpoint Signaling
Positive Regulation Of Transforming Growth Factor Beta2 Production
Cellular Response To Oxidative Stress
P38MAPK Cascade
Positive Regulation Of Neuron Apoptotic Process
Histone H4 Acetylation
Histone H2B Acetylation
Cellular Lipid Metabolic Process
Fat Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of DNA-binding Transcription Factor Activity
Neurofilament Cytoskeleton Organization
Adipose Tissue Development
Motor Neuron Apoptotic Process
Amelogenesis
Hepatocyte Apoptotic Process
Cellular Response To Virus
Positive Regulation Of Cardiac Muscle Myoblast Proliferation
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Apoptotic Process Involved In Development
Pathways
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Signaling by Activin
Signaling by BMP
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
RUNX2 regulates bone development
RUNX3 regulates CDKN1A transcription
RUNX3 regulates BCL2L11 (BIM) transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Transcriptional activation of mitochondrial biogenesis
HATs acetylate histones
Circadian Clock
Activation of the AP-1 family of transcription factors
TP53 Regulates Transcription of DNA Repair Genes
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
NGF-stimulated transcription
NGF-stimulated transcription
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK4 (GCN2) to amino acid deficiency
Heme signaling
Drugs
Pseudoephedrine
Diseases
GWAS
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Immune response to anthrax vaccine (
22658931
)
Metabolite levels (
23823483
)
Oligoclonal band status in multiple sclerosis (
25616667
)
Intake of total sugars (
31005972
)
Metabolite levels (
23823483
)
Interacting Genes
214 interacting genes:
ACVR1B
AKT1
ALDOB
AOPEP
AP2B1
APBB2
AR
ARFRP1
ARL5B
ATF2
ATF7IP
BAAT
BCAS3
BEX1
BRCA1
BTRC
CAMK2G
CCDC180
CD59
CDC14B
CEBPA
CEBPB
CEBPD
CHEK1
CITED1
CNKSR1
COPS5
CREBBP
CSH1
CSH2
CTCF
CTNNB1
CYFIP2
DACH1
DCP1A
DCP1B
DKK3
DLX1
DNAJB2
DNMT3L
DVL1
ECSIT
EEF1A1
EID2
EIF2AK4
EP300
ERBIN
ESR1
ESR2
ETV4
EWSR1
FANCC
FBLN1
FBP2
FBXO30
FBXO34
FHL2
FHL3
FN1
FOXG1
FOXH1
FOXO1
FOXO3
FOXO4
FSTL3
GATA2
GLI3
GPNMB
GREB1
HDGF
HDLBP
HEMGN
HMG20A
HNF4A
HOXA9
HOXC8
HRAS
HYAL2
IL24
ITK
JUN
JUNB
JUND
LAMTOR5
LEF1
LMO4
LRATD2
LYPD3
MAPK1
MAPK13
MAX
MDM4
MECOM
MEF2A
MEX3B
MSANTD3
MYOD1
NAT8
NEK6
NELFCD
NFIA
NFKBID
NKX3-2
NOTCH4
NR0B2
NRAS
NUAK2
NUP214
OTUB1
PAK1
PAPPA2
PARD3
PBK
PIAS1
PIAS2
PIAS3
PIAS4
PLG
PLK4
PPP2CB
PPP3R2
PRKAR1B
PRKAR2A
PRPF40A
PSG2
PSG9
PSMD11
RAB13
RAB25
RAB2B
RAB34
RAB38
RAB3B
RAC2
RALA
RASD2
RASL12
RASSF5
RBL1
RELA
RFX1
RHEBL1
RHOD
RHOG
RHOJ
RIPK2
RMND5B
RPL28
RPS27A
RRAS2
RSPH14
S100A14
SASH3
SERPINA1
SERPINB5
SFRP2
SFRP4
SHC1
SKI
SKIL
SKP2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD7
SMAD9
SNIP1
SNRNP70
SNW1
SOX12
SP1
SPTBN1
SQSTM1
STK11IP
STK35
STUB1
STX17
TCTA
TDG
TENM3
TFE3
TGFBR1
TGFBR2
TGFBRAP1
THRSP
TIAF1
TLE5
TM9SF2
TOB1
TRAP1
TSSK3
TSTD2
UBA52
UBB
UBE2I
UBE2L3
UBE2Z
UHRF2
USB1
USP10
USP4
USP9X
WWOX
XPO5
ZBED5
ZBTB7A
ZIC1
ZMYM2
ZNF189
ZNF423
ZNF510
ZNF521
ZNF8
66 interacting genes:
APP
AR
ATF3
ATF4
ATF7
BACH1
BANP
BATF
CCDC6
CCND1
CEBPA
CEBPB
CEBPG
CENPQ
CFLAR
CREB5
CSNK2A1
CSNK2A2
CYP27B1
DDIT3
DNMT3L
EDF1
ETS1
EXOSC8
FOS
FOSB
FOSL1
FOSL2
GTF2F2
H2BC21
HMGA1
IRF2BP1
JDP2
JUN
KIFC3
LHX8
MACROH2A1
MAPK1
MAPK10
MAPK11
MAPK13
MAPK14
MAPK8
MAPK9
MAPKAPK5
MLH1
NBN
NCOA6
PIAS2
PML
PRKCE
RB1
RNF4
RPS6KA5
RUVBL2
SMAD3
SMAD4
SPOPL
SRA1
SUMO1
THRB
UBE2I
USP14
UTF1
XPO1
YY1
Entrez ID
4089
1386
HPRD ID
02995
00443
Ensembl ID
ENSG00000141646
ENSG00000115966
Uniprot IDs
A0A024R274
Q13485
A4D7V5
P15336
PDB IDs
1DD1
1G88
1MR1
1U7F
1U7V
1YGS
5C4V
5MEY
5MEZ
5MF0
5UWU
1BHI
1T2K
4H36
6ZQS
6ZR5
Enriched GO Terms of Interacting Partners
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